Development of an Experimental Home Bleaching Agent Containing Chitosan Nanoparticles Loaded with Gypsophila arrostii Extract

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Objectives: Peroxide alternative agents are currently being developed to provide a safe and effective tooth whitening treatment, given the potential for these agents to affect hard dental tissue. In this study, it is aimed to produce an experimental home whitening gel containing Gypsophila arrostii extract (GE) loaded chitosan nanoparticles with controlled release property. Materials and Methods: GE was prepared in two different ways using water or ethanol, and the saponin amounts of both extracts were measured using gravimetric analysis methods. GE-loaded chitosan nanoparticles (GECNPs) prepared by the ionic gelation method were investigated in terms of size, zeta potential, polydispersity index (PdI), encapsulation efficiency, and release profile. The significance level was set at p<0.05. Results: The water-based extract was preferred for encapsulation due to its statistically significantly higher percentage of saponin content (45.38 ± 3.050396%) (p=0.335). According to the characterization results, GECNPs were 651±8.34 nm in average particle size, 0.242±0.02 PdI, and 44.7±0.21 mV zeta potential. Encapsulation efficiency was determined as 97.41±3.02%. GE release from GECNP was calculated as 94.11±4.03% at 48 h, and the drug release rate increased by adding peroxides. Conclusions: The controlled release system of Gypsophila arrosti extract-loaded CNPs was successfully synthesized to develop an experimental home-bleaching gel as an alternative and promising approach.

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