PolyDeep Advance 1: Clinical Validation of a Computer-Aided Detection System for Colorectal Polyp Detection with a Second Observer Design
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Le résumé fourni par la source
Background: PolyDeep is a computer-aided detection and characterization system that has demonstrated a high diagnostic yield for in vitro detection of colorectal polyps. Our objective is to compare the diagnostic performance of expert endoscopists and PolyDeep for colorectal polyp detection. Methods: PolyDeep Advance 1 (NCT05514301) is an unicentric diagnostic test study with a second observer design. Endoscopists performed colonoscopy blinded to PolyDeep’s detection results. The main endpoint was the sensitivity for colorectal polyp (adenoma, serrated or hyperplastic lesion) detection. The secondary endpoints were the diagnostic performance for diminutive lesions (≤5 mm), neoplasia (adenoma, serrated lesion) and adenoma detection. Results: We included 205 patients (55.1% male, 63.0 ± 6.2 years of age) referred to colonoscopy (positive faecal immunochemical occult blood test = 60.5%, surveillance colonoscopy = 39.5%). We excluded eight patients due to incomplete colonoscopy. Endoscopists detected 384 lesions, of which 39 were not detected by PolyDeep. In contrast, PolyDeep predicted 410 possible additional lesions, 26 of these predictions confirmed by endoscopists as lesions, resulting in a potential 6.8% detection increase with respect to the 384 lesions detected by the endoscopists. In total, 410 lesions were detected, 20 were not retrieved, five were colorectal adenocarcinoma, 343 were colorectal polyps (231 adenomas, 39 serrated and 73 hyperplastic polyps), 42 were normal mucosa and 289 were ≤5 mm. We did not find statistically significant differences between endoscopists and PolyDeep for colorectal polyp detection (Sensitivity = 94.2%, 91.5%, p = 0.2; Specificity = 9.5%, 14.3%, p = 0.7), diminutive lesions (Sensitivity = 92.3%, 89.5%, p = 0.4; Specificity = 9.8%, 14.6%, p = 0.7), neoplasia (Sensitivity = 95.2%, 92.9%, p = 0.3; Specificity = 9.6%, 13.9%, p = 0.4) and adenoma detection (Sensitivity = 94.4%, 92.6%, p = 0.5; Specificity = 7.2%, 11.8%, p = 0.2). Conclusions: Expert endoscopists and PolyDeep have similar diagnostic performance for colorectal polyp detection.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- PolyDeep Advance 1: Clinical Validation of a Computer-Aided Detection System for Colorectal Polyp Detection with a Second Observer Design
- Date Crossref
- 13/02/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Fundación Pública Galega de Medicina Xenómica pays non établi dans la noticeStructure de recherche
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Complejo Hospitalario de Ourense pays non établi dans la noticeÉtablissement de santé
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Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas pays non établi dans la noticeStructure de recherche
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Galicia Sur Biomedical Foundation pays non établi dans la noticeInstitution
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Universidade do Porto i3S - Instituto de Investigação e Inovação em Saúde pays non établi dans la noticeStructure de recherche
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Hospital Universitario de Ourense Fundación Pública Galega de Investigación Biomédica Galicia Sur pays non établi dans la noticeÉtablissement de santé
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University of Vigo Department of Computer Science pays non établi dans la noticeUniversité ou école supérieure
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Galicia Sur Health Research Institute (IIS Galicia Sur) Next Generation Computer Systems Group (SING) Research Group pays non établi dans la noticeStructure de recherche
Fundación Pública Galega de Medicina Xenómica, Servicio Gallego de Salud et Complejo Hospitalario de Ourense, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.