Ce Single Atom with Cascaded Self‐Circulating Enzyme‐Like Activities and Photothermal Activities for Cancer Therapy
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Le résumé fourni par la source
Abstract Specific regulation of the tumor microenvironment (TME) is a potential strategy for tumor therapy. Although many TME‐responsive nanozymes have been developed for tumor therapy, the limited substrates affect the therapeutic effect. In this study, cerium single‐atom nanozymes (Ce SAs) are prepared by immobilizing cerium (Ce) using zeolitic imidazolate framework‐8 (ZIF‐8) as a precursor. The reversible conversion between Ce 3+ and Ce 4+ endows Ce SAs with multiple enzyme‐like activities, such as peroxidase (POD)‐like activity, oxidase (OD)‐like activity, catalase (CAT)‐like activity, glucose oxidase (GOD)‐like activity, and glutathione peroxidase (GSH‐Px)‐like activity. All of the above enzyme activities give Ce SAs cascade self‐circulation properties and can be used for tumor therapy in the TME. In addition, the prepared Ce SAs also have photothermal properties, which can achieve photothermal therapy (PTT) of tumor cells under 808 nm near‐infrared (NIR) irradiation. Combining the cascade self‐cycling enzyme‐like activities and the photothermal properties of Ce SAs, this synergistic therapy makes Ce SAs have attractive efficacy in tumor treatment.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Ce Single Atom with Cascaded Self‐Circulating Enzyme‐Like Activities and Photothermal Activities for Cancer Therapy
- Date Crossref
- 10/02/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nankai University pays non établi dans la noticeUniversité ou école supérieure
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Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering & pays non établi dans la noticeUniversité ou école supérieure
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School of Materials Science and Engineering & National Institute for Advanced Materials Tianjin Key Lab for Rare Earth Materials and Applications pays non établi dans la noticeUniversité ou école supérieure
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Department of Minimally Invasive Spine Surgery The First Affiliated Hospital of Shandong Second Medical University Weifang Shandong 261000 P. R. China Department of Minimally Invasive Spine Surgery pays non établi dans la noticeUniversité ou école supérieure
Nankai University, Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering & et Tianjin Key Lab for Rare Earth Materials and Applications — School of Materials Science and Engineering & National Institute for Advanced Materials, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.