Vitamin E (α-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults
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Le résumé fourni par la source
Vitamin E, primarily in its active form α-tocopherol, is a well-known antioxidant that protects cells from oxidative stress and free radical damage. It plays an essential role in maintaining cellular integrity and supporting immune function, making Vitamin E a widely popular and easily accessible dietary supplement for overall health and wellness. However, high-dose Vitamin E supplementation has become a concern related to potential risks. The scientific research surrounding the safety and efficacy of Vitamin E is complex yet emphasizes a balance in the use of Vitamin E supplementation. Excessive or high-dose supplementation causes a shift in this balance, as Vitamin E's beneficial antioxidant properties are outweighed by harmful interference in normal cellular processes such as immunity, cell growth, and oxidative stress. An additional complication involves Vitamin E's anticoagulant effects, which have been shown to amplify the risk of bleeding when high-dose supplementation is combined with blood thinners such as warfarin and aspirin. Studies have linked high-dose Vitamin E supplementation to adverse outcomes, including enhanced risks of all-cause mortality, hemorrhagic stroke, cardiovascular events, and certain cancers. These risks are particularly significant for individuals with pre-existing health conditions such as heart failure, coagulation disorders, or a history of stroke. The potential risk of adverse side effects emphasizes the need for further research into high-dose Vitamin E supplementation. This review will provide a comprehensive analysis of Vitamin E's multifaceted role in health and physiology, focusing on navigating the balance between potential benefits and risks in supplementation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vitamin E (α-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults
- Date Crossref
- 07/02/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of the Pacific pays non établi dans la noticeUniversité ou école supérieure
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Louisiana State University Health Sciences Center Shreveport Department of Anesthesiology pays non établi dans la noticeÉtablissement de santé
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Fondazione Roma pays non établi dans la noticeOrganisation à but non lucratif
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Fondazione Paolo Procacci pays non établi dans la noticeOrganisation à but non lucratif
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Thomas J. Long School of Pharmacy and Health Sciences Department of Pharmacy Practice pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Pain Medicine pays non établi dans la noticeInstitution
University of the Pacific, Department of Anesthesiology — Louisiana State University Health Sciences Center Shreveport et Fondazione Roma, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.