Accès ouvert déclaré 2025 article

The influence of prestroke disability on outcome in patients with a low Alberta Stroke Program Early CT Score who underwent endovascular thrombectomy

Hidetoshi Matsukawa, Kazutaka Uchida, Sameh Samir Elawady, Conor M. Cunningham, Mohammad‐Mahdi Sowlat, Ilko Maier, Pascal M. Jabbour, Joon-Tae Kim, Stacey Q Wolfe, Ansaar Rai, Robert M. Starke, Marios‐Nikos Psychogios, Edgar Andres Samaniego, Adam Stephen Arthur, Shinichi Yoshimura, Hugo Cuellar, Jonathan Andrew Grossberg, Ali Mostafa Alawieh, Daniele Giuseppe Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam J. Polifka, Joshua W. Osbun, Roberto Javier Crosa, Charles Christian Matouk, Min Sik Park, Michael R. Levitt, Waleed Brinjikji, Mark B. Moss, Richard Williamson, Pedro Navía, Peter Tze Man Kan, Reade Andrew De Leacy, Shakeel A. Chowdhry, Mohamad Ezzeldin, Alejandro M Spiotta

2Citations signalées, ce qui n’est pas une note de qualité

33Institutions déclarées

8Pays d’affiliation déclarés

Rattachement africain : us, jp, de, kr, ch, it, pt, es. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

OBJECTIVE: The definitive influence of prestroke disability on outcomes in patients with a low Alberta Stroke Program Early CT Score (ASPECTS) treated with endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) remains unknown. This study aimed to investigate the impact of prestroke disability on outcomes in this specific population. METHODS: Data from 32 international centers for AIS-LVO patients with a low ASPECTS who underwent EVT between January 2013 and December 2022 were analyzed retrospectively. Low ASPECTS and prestroke disability were defined as ASPECTS values of 2-5 and prestroke modified Rankin Scale (mRS) score ≥ 2. The primary outcome was a return to the prestroke mRS score at 90 days. Secondary outcomes were independent ambulation (mRS scores of 0-3) or a return to the prestroke mRS score at 90 days, good functional outcome (mRS scores of 0-2) or a return to the prestroke mRS score at 90 days, successful recanalization, and 90-day mortality. Safety outcomes were any intracranial hemorrhage or symptomatic intracranial hemorrhage. A symptomatic intracranial hemorrhage was defined as an intracranial hemorrhage with an associated worsening of ≥ 4 points in the National Institutes of Health Stroke Scale score. Outcomes were compared between patients with and without prestroke disability. RESULTS: Of 293 patients, 50 (17.1%) had a prestroke disability. Of 50 patients, 20 (40.0%), 24 (48.0%), and 6 (12.0%) had prestroke mRS scores of 2, 3, and 4, respectively. The primary outcome showed no significant difference between the two groups. Compared with patients without prestroke disability, those with prestroke disability had a significantly smaller proportion of independent ambulation or return to prestroke mRS score (adjusted OR 0.13, 95% CI 0.03-0.53) and good functional outcome or return to prestroke mRS score (adjusted OR 0.21, 95% CI 0.05-0.91). Other secondary and safety outcomes showed no significant difference between the two groups. CONCLUSIONS: The present study indicated that prestroke disability was not associated with a return to the prestroke mRS score at 90 days or intracranial hemorrhage. Physicians should not routinely exclude AIS-LVO patients with a low ASPECTS who have prestroke disability from EVT based on prestroke disability alone.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: The influence of prestroke disability on outcome in patients with a low Alberta Stroke Program Early CT Score who underwent endovascular thrombectomy
Date Crossref: 01/07/2025
Éditeur: Journal of Neurosurgery Publishing Group (JNSPG)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Medical University of South Carolina Department of Neurosurgery pays non établi dans la notice
Université ou école supérieure
Hyogo University pays non établi dans la notice
Université ou école supérieure
Universitätsmedizin Göttingen pays non établi dans la notice
Établissement de santé
University of Göttingen pays non établi dans la notice
Université ou école supérieure
Thomas Jefferson University Hospital Department of Neurosurgery pays non établi dans la notice
Établissement de santé
Jefferson University Hospitals pays non établi dans la notice
Établissement de santé
Chonnam National University Hospital pays non établi dans la notice
Établissement de santé
Wake Forest University pays non établi dans la notice
Université ou école supérieure
University of Miami Health System Department of Neurosurgery pays non établi dans la notice
Établissement de santé
University of Basel Department of Interventional and Diagnostical Neuroradiology pays non établi dans la notice
Université ou école supérieure
University of Iowa Hospitals and Clinics Department of Neurology pays non établi dans la notice
Établissement de santé
University of Tennessee Health Science Center Department of Neurosurgery pays non établi dans la notice
Université ou école supérieure

Department of Neurosurgery — Medical University of South Carolina, Hyogo University et Universitätsmedizin Göttingen, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Acute Ischemic Stroke ManagementStroke Rehabilitation and RecoveryCerebrovascular and Carotid Artery Diseases

Lire en accès ouvert Consulter la publication primaire Ouvrir le DOI