Multidimensional outcome of first-episode psychosis: a network analysis
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Le résumé fourni par la source
BACKGROUND: Few studies have examined the long-term outcomes of first-episode psychosis (FEP) among patients beyond symptomatic and functional remission. This study aimed to broaden the scope of outcome indicators by examining the relationships between 12 outcomes of FEP patients at 20.9 years after their initial diagnosis. METHODS: At follow-up, 220 out of 550 original patients underwent a new assessment. Twelve outcomes were assessed via semistructured interviews and complementary scales: symptom severity, functional impairment, personal recovery, social disadvantage, physical health, number of suicide attempts, number of episodes, current drug use, dose-years of antipsychotics (DYAps), cognitive impairment, motor abnormalities, and DSM-5 final diagnosis. The relationships between these outcome measures were investigated using Spearman's correlation analysis and exploratory factor analysis, while the specific connections between outcomes were ascertained using network analysis. RESULTS: The outcomes were significantly correlated; specifically, symptom severity, functioning, and personal recovery showed the strongest correlations. Exploratory factor analysis of the 12 outcomes revealed two factors, with 11 of the 12 outcomes loading on the first factor. Network analysis revealed that symptom severity, functioning, social disadvantage, diagnosis, cognitive impairment, DYAps, and number of episodes were the most interconnected outcomes. CONCLUSION: Network analysis provided new insights into the heterogeneity between outcomes among patients with FEP. By considering outcomes beyond symptom severity, the rich net of interconnections elucidated herein can facilitate the development of interventions that target potentially modifiable outcomes and generalize their impact on the most interconnected outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multidimensional outcome of first-episode psychosis: a network analysis
- Date Crossref
- 01/01/2025
- Éditeur
- Cambridge University Press (CUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Navarre Institute of Health Research pays non établi dans la noticeUniversité ou école supérieure
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Universidad Pública de Navarra (UPNA) pays non établi dans la noticeUniversité ou école supérieure
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Servicio Navarro de Salud pays non établi dans la noticeOrganisme public
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Hospital Universitario de Navarra Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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Navarra Institute for Health Research (IdiSNA) pays non établi dans la noticeStructure de recherche
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Departament of Health Sciences pays non établi dans la noticeInstitution
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Mental Health Department pays non établi dans la noticeInstitution
Navarre Institute of Health Research, Universidad Pública de Navarra (UPNA) et Servicio Navarro de Salud, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.