Platinum( ii ) complexes of aryl guanidine-like derivatives as potential anticancer agents: between coordination and cyclometallation

Résumé fourni par la source

activation of platinum arylguanidine complexes with acetonitrile to create a bidentate aryl iminoguanidine Pt(ii) complex were achieved. Cyclometallation methodology was extended to create a water-stable conjugate incorporating two Pt(ii) ions and a diaryl bis-guanidine DNA minor groove binder. Several crystal structures were obtained confirming these complexation modes. The cyclometallated Pt(ii) complexes were particularly stable to aqueous environments and were tested for Reactive Oxygen Species generation and anticancer activity in a leukaemia cancer cell line.

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