Generating functional plasmid origins with OriGen

Résumé fourni par la source

ABSTRACT While generative artificial intelligence has shown promise for biological design, no computational system has yet created sequences proven capable of replication. Focusing on plasmids as minimal replicating systems, we develop OriGen, a language model that generates novel plasmid origins of replication while maintaining essential functional elements. We experimentally validate OriGen’s ability to create functional origins that diverge from existing wild types, demonstrating the model’s capacity to capture the complex and often enigmatic mechanisms of biological replication.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.