The Impact of Prognostic Factors on Survival in Patients with Non-Metastatic Invasive Breast Cancer: A Single-Center Experience

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Background: Breast cancer (BC) is the most prevalent and lethal cancer in women. Prognostic factors are used to guide treatment and predict the prognosis. This study aims to assess the influence of prognostic factors on the survival of patients with non-metastatic invasive BC. Methods: Data from invasive BC patients admitted to Medical Oncology Department of Süleyman Demirel University between October 2002 and October 2013 were retrospectively reviewed. Clinicopathologic features, treatment information, and follow-up data were noted. The Kaplan-Meier method was used to estimate survival functions. Multivariate Cox regression analysis was performed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS), with p values <0.05 for univariate results Results: A total of 717 patients entered the study. The median follow-up time was 41 months. Recurrence was detected in 17.4% of the patients, and 111 (15.5%) patients died. The 5- and 10-year DFS rates were 78% and 61%; OS rates were 86% and 70%, respectively. In multivariate analyses, DFS and OS were associated with axillary lymph node involvement (P<0.001 and P<0.05, respectively), tumor size (P<0.05), and histologic grade (P<0.05); whereas human epidermal growth factor receptor 2 positivity had only a statistically significant effect on poor OS (P=0.004). Conclusion: Comparable to previous studies, traditional prognostic factors had an important impact on prognosis in invasive BC patients. In the current era, where more conservative surgical approaches and new, effective systemic neoadjuvant and adjuvant therapies are widely used, the importance of the traditional prognostic factors highlighted in our study needs to be established by further studies.

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