2025 article

Life’s Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes

H.P. Chen, Ruyi Li, Sen Liu, Shiyu Zhao, Tianyu Guo, Shufan Tian, Jiale Zhong, Zi-Jun Tang, Zhiming Ge, Jia‐Wei Xia, Tingting Geng, Xiong‐Fei Pan, An Pan, Frank Qian, Gang Liu

7Citations signalées, ce qui n’est pas une note de qualité

5Institutions déclarées

2Pays d’affiliation déclarés

Rattachement africain : cn, us. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

AIMS: To assess whether better cardiovascular health (CVH) is associated with a lower long-term risk of cardiovascular disease (CVD) in women with a history of adverse pregnancy outcomes (APOs). METHODS AND RESULTS: Using data from the UK Biobank prospective cohort, we included 2263 participants with prior APOs and 107 260 participants without prior APOs. Life's Essential 8 (LE8) score was assessed at baseline. Multivariable-adjusted Cox models were used to estimate the associations between LE8 score and CVD events. Over a median 13.5 years of follow-up, 11 134 incident CVD events were documented. Among women with prior APOs, the incidence of total CVD was significantly lower in the top tertile compared with the bottom tertile, with a hazard ratio (HR) [95% confidence interval (CI)] of 0.43 (0.29, 0.65). A similar trend was observed in women without APOs, with an HR (95% CI) of 0.55 (0.53, 0.58). With respect to the individual CVD outcomes, among women with APOs, only the associations with coronary heart disease (CHD), HR (95% CI) for T3 vs. T1: 0.30 (0.17, 0.55), and atrial fibrillation (AF): 0.47 (0.24, 0.91) achieved statistical significance. Women with high LE8 score and prior APOs had a similar long-term cardiovascular risk compared with women with high LE8 score and no prior APOs [0.95 (0.63, 1.44)]. CONCLUSION: Among women with a history of APOs, better CVH as assessed using LE8 was associated with a significantly lower incidence of CVD, particularly CHD and AF. The excess risk associated with APOs appears to be attenuated among those with a high LE8 score.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Life’s Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes
Date Crossref: 31/01/2025
Éditeur: Oxford University Press (OUP)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Huazhong University of Science and Technology pays non établi dans la notice
Université ou école supérieure
National Medical Products Administration pays non établi dans la notice
Organisme public
Sichuan University pays non établi dans la notice
Université ou école supérieure
Boston University Section of Cardiovascular Medicine pays non établi dans la notice
Université ou école supérieure
Boston Medical Center pays non établi dans la notice
Établissement de santé
School of Public Health Department of Nutrition and Food Hygiene pays non établi dans la notice
Université ou école supérieure
West China Second University Hospital Department of Obstetrics and Gynecology pays non établi dans la notice
Université ou école supérieure

Huazhong University of Science and Technology, National Medical Products Administration et Sichuan University, avec 4 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Cardiovascular Health and Risk FactorsGestational Diabetes Research and ManagementBirth, Development, and Health

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