Accès ouvert déclaré
2025
article
Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients
Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Darío Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto J. Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, Marco Abastanotti, Mohamed Abdel-Maboud Abdel-Maboud, Abdelfatah Abdellateef Abdelmageed, E E Abdullah, Ahmed Mohammed Abodina, Aymen Abuelyamen, Abdurraouf Abusalama, Tareg Abdalla Abuzaid, Romina Aceto, Stefano Addesa, Daniela Alampi, Amer Aldhalia, Risoli Alessio, Maytham Al-Juaifari, Raja Ahmed Alqandouz, Mohammed Al‐Sadawi, Marco Anderloni, Cannone Andrea, Enrico Andriolo, Botto Anna, Benvenuto Antonini, Gian Marco Anzellotti, Matteo Aritzu, Ahmed K. Awad, Flavio Badii, Hibah Bileid Bakeer, Aziza Bakri, Andrea Ballin, Massimo Barattini, Mattia Barotti, Mara Bassi, Mattia Bellandi, Marzia Bellin, Agrippino Bellissima, Annalisa Benini, Francesco Berruto, Giacomo Berta, Marco Berti, Emanuela Biagioni, Eugenio Biamonte, Giacomo Bianchetti, Andrea Bianchin, Manuela Biasetto, Muhannud Binnawara, Maria Bisi, Maria Maddalena Bitondo, Nicoletta Boffa, Michela Bombino, Benedetta Bonazzi, Elisa Bonetta, Elisa Boni, Sara Borga, Vincenzo Bosco, Gloria Boscolo, Veronica Bozzon, Luca Brazzi, Alessandro Bristot, Niccolò Brumana, Andrea Bruni, Chiara Bruscagnin, Stefano Busani, Guido Bussone, Pietro Caironi, Tiffany Calocero, Matteo Campagnolo, Claudine Canepa, Riccardo Carlon, Alfonso Carrara, Antonio Castelli, Giulia Catalisano, Martina Cavinato, Francesca Ceccaroni, Cecconi Ml, Martina Cedrone, Marcello Ceola Graziadei, Matteo Cesana, Nicola Cilloni, Enrico Colombo, Riccardo Colombo, Irene Coloretti, Sabrina Congedi, A. Corea, Nicola Cornacchia, Silvia Corrado, Valentina Cricca, Chiara Crivellari, Wanda Cursio, Ernesto Dalla Mora, Lorenzo Dall’Ara, Vinicio Danzi, Luca Davicco, Alessandro De Cassai, Alessandro Devigili, Di Blasi S, Antonino Di Fede, Antonia Di Giannantonio, Pierluigi Di Giannatale, Luna Di Matteo, Giovanni Di Noto, Luca Di Tizio, Katia Donadello, Chiara Donatelli, Deyaa Elden Elbakheet, Gallo Elisa, Moataz Maher Emara, Haneen Esaadi, Mirca Fabbris, Massimo Ferluga, Luigi Ferrante, Francesco Filippone, E Finotto, Ilaria Fior, Edoardo Forin, Tommaso Fossali, Rosa Fracchia, Salvo Francesco, Alessandra Gioia Francesconi, Nicola Franchetti, Sara Frisella, Regina Frontera, Roberto Fumagalli, Elisa Furlani, L Gamberini, Elisa Gamberini, Emiliano Gamberini, Leonardo Gandolfi, Bernardetta Ganzerla, Silvia Gasperi, Ilenia Gatto, Federico Geraldini, Monica Geremia, Marco Giani, Massimo Girardis, L Giuntoli, Ilaria Godi, Gianlorenzo Golino, Beatrice Gottardi, Antonio Grande, Massimiliano Greco, Daniela Guerra, Amedeo Guzzardella, Abdurrahman Haddud, Hashim Talib Hashim, Aliaë Mohamed-Hussein, Blangetti Ilaria, Teresa Iob, Giovanni Carmine Iovino, Mariachiara Ippolito, Stefano Isgrò, Cristina Jovinelli, Abdulmuhaymin Khalleefah, A Kredan, Riccardo La Rosa, Claudio La Spisa, Luca Landolfi, Thomas Langer, Annalisa Lerose, Federico Linassi, Jacopo Lion, Giulia Lo Scrudato, Antonella Lombardo, F Longhini, Marta Lubian, G. Luccarelli, Alberto Lucchini, Aurora Magliocca, Giorgio MAIORELLI, Ilaria Mariani, Anna Marinello, Francesco Marrazzo, Marina Martin, Nicolò Martinetti, Ettore Martinez, Alvise Martini, Marilena Matteo, James Mattson, Jessica Giuseppina Maugeri, Federica Mazzanti, Francesca Medici, L Melchior, Lorenza Menato, Beatrice Milan, Maiseloon Mogahed, Francesco Mojoli, Silvia Mongodi, Jonathan Montomoli, Giorgia Montrucchio, Lorenza Moretto, Giuseppe Moschini, Elena Munari, Giuseppe Neri, Rosella Nicoletti, Alice Nova, Nicoletta Nuzzo, Andrea Maria Olivieri, Sara Olivieri, Ongaro Sebastiano, Anita Orlando, Eman Othman, Davide Ottolina, Michele Pagani, Giacomo Paluzzano, G. Panciera, Valesano Paolo, Francesco Papaccio, Marcella Parente, Zoe Parimisi, Laura Pasin, Lucia Alessandra Pasqua, Federica Pavan, Matteo Perona, Paolo Persona, Tommaso Pettenuzzo, Angelo Pezzi, Elisa Pistollato, Enrico Polati, Melissa Polo Fritz, Gilda Ponzone, Matteo Pozzi, Antonella Prandini, Nicoletta Predonzani, Chiara Premoli, Davide Raimondi Cominesi, Jacopo Rama, Linda Ramahi, Ginevra Randon, Marta Repishti, Andrea Restivo, Mara Ricci, Veronica Rizzello, Erika Roat, Monica Rocco, Andrea Rodi, Egle Rondelli, Vincenzo Russotto, Debora Saggioro, Francesco Saglietti, Abdurraouf Said, Gabriele Sales, Abdulhamid Ahmed Saliga, Reem Salih, Michele Salvagno, Antonio Massimo Sammarco, Jacopo Santi, Carola Santi, Elisabetta Saraceni, Gaetano Scaramuzzo, Chiara Schiavolin, Valerio Schinetti, Vittorio Schweiger, Elena Serafini, Teodora Serana, Luca Serano, Laila Esnoussi Shalabi, Haitam Shames, Salvatore Simari, Caterina Simoni, Simone Smiraglia, Fabio Soccorsi, Alessandra Soragni, Silvana Sorrentino, Savino Spadaro, Stefano Spina, Marta Talamonti, Francesco Talarico, Chiara Natalia Tartivita, T. Tenaglia, Francesco Terranova, Denise Testini, Fabio Toffoletto, Anna Toniolo, Morena Tonzar, Giulia Torsello, Tommaso Travaglini, Fabrizio Tritapepe, Luigi Tritapepe, Letizia Troisi, Fabrizio Turvani, Lucrezia Urso, Rita Vaia Liouras, Paolo Valente, Maria Sole Vallecoccia, Paola Vergano, Sara Vergine, L Vetrugno, Vanessa Zambelli, Mostafa Zanaty, Francesco Zarantonello, Michela Zardin, Francesca Zini, Eugenia Zoppellaro
10Citations signalées — pas une note de qualité
16Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Prone position has been diffusely applied in mechanically ventilated COVID-19 patients. Our aim is ascertaining the association between the physiologic response and the length of the first cycle of prone position and intensive care unit (ICU) mortality. METHODS: International registry including COVID-19 adult patients who underwent prone positioning. We measured the difference for arterial partial pressure of oxygen to inspired fraction of oxygen ratio (PaO2/FiO2), ventilatory ratio, and respiratory system compliance (Crs) between baseline supine position and at either the end of the first cycle of prone position (Delta-PP) or re-supination (Delta-PostPP). RESULTS: We enrolled 1816 patients from 53 centers. Delta-PP and Delta-PostPP for PaO2/FiO2 were both associated with ICU mortality [OR (95% CI) 0.48 (0.38, 0.59), and OR (95% CI) 0.60 (0.52, 0.68), respectively]. Ventilatory ratio had a non-linear relationship with ICU mortality for Delta-PP (p = 0.022) and Delta-PostPP (p = 0.004). Delta-PP, while not Delta-PostPP, for Crs was associated with ICU mortality [OR (95% CI) 0.80 (0.65, 0.98)]. The length of the first cycle of prone position showed an inverse relationship with ICU mortality [OR (95% CI) 0.82 (0.73, 0.91)]. At the multivariable analysis, the duration of the first cycle of prone position, Delta-PP and Delta-PostPP for PaO2/FiO2, and Delta-PostPP for ventilatory ratio were independently associated with ICU mortality. CONCLUSION: In COVID-19 patients with acute respiratory failure receiving invasive mechanical ventilation and prone positioning, the physiological response to prone position is associated with ICU mortality. Prolonging the duration of the first cycle of prone position is associated with improved survival.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Respiratory Support and MechanismsIntraoperative Neuromonitoring and Anesthetic EffectsPneumothorax, Barotrauma, Emphysema