Effects of chronic manganese administration on motor and non-motor disorders similar to Parkinson’s disease in rats: involvement of oxidative stress

Résumé fourni par la source

The manganese (Mn) toxicity is often associated with neurological symptoms similar to Parkinson’s disease, likely due to oxidative stress caused by the accumulation of the metal in neuronal structures. This study aims to assess the neurotoxic effects of chronic Mn exposure on motor and non-motor disorders similar to Parkinson’s disease. Male Wistar rats were exposed to different doses of Mn (6 mg/kg, 25 mg/kg, 30 mg/kg, and 40 mg/kg) through daily intraperitoneal injections for 12 weeks. The neurotoxic effects of Mn were evaluated through behavioral, locomotor, and olfactory tests. The rats were then euthanized to assess oxidative stress in the affected nerve structures. Our results demonstrate that chronic exposure to Mn produced adverse effects, with doses of 25 mg/kg, 30 mg/kg, and 40 mg/kg inducing symptoms similar to those observed in Parkinson’s disease, affecting locomotion, olfaction, and affective behavior. The 6 mg/kg dose, however, proved relatively harmless. Neurochemical analyses revealed a significant increase in nitric oxide and lipid peroxidation levels with decreased catalase activity in the hippocampus, striatum, frontal and prefrontal cortex, and olfactory bulb. In summary, chronic exposure to Mn induces dose-dependent neurotoxic effects, highlighting the need for increased monitoring of this metal’s levels to prevent health risks.

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