Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
Rattachement africain : pk, sa, bg. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The current research focused on the synthesis of two series of pyrazole derivatives and evaluation of their insecticidal effectiveness. In the first series, seven pyrazole Schiff bases 3a-g were successfully synthesized with yields (79–95%) by condensing phenylfuran-2-carbaldehyde with substituted pyrazole rings. In the second series, eleven amino acid-pyrazole conjugates 6a–k were synthesized utilizing acetic acid, sulfuric acid, morpholine, and EDC. HCl achieving yields of 59% to 94%. The synthesized compounds were assessed for their chemotherapeutic efficacy against locusts and termites by calculating LC 50 values, thereby determining their potential as anti-termite and anti-locust agents. Among the eighteen synthesized pyrazole compounds, the Schiff base pyrazole molecules 3f (LC 50 = 0.001 μg/mL) and 3d (LC 50 = 0.006 μg/mL) demonstrated excellent anti-termite activity compared to the reference drug fipronil (LC 50 = 0.038 μg/mL). Pyrazole derivative 6 h with LC 50 = 47.68 μg/mL exhibited superior anti-locust activity than the reference drug fipronil (LC 50 = 63.09 μg/mL). Additionally, compound 3b, containing NO 2 functionality at the meta position, exhibited notable and significant anti-locust activity with an LC 50 values of 100.00 μg/mL. However, the highest mortality was caused by the glycine conjugate of fipronil 6 h of the 2nd series with an LC 50 value of 47.68 μg/mL, which also proved to be a potent anti-locust agent. This study explores the efficacy of biologically active pyrazole structures as potential insecticidal agents through a combination of virtual molecular docking analysis and biological experimental investigations. The results demonstrate a strong correlation between the computational predictions and experimental outcomes, suggesting that the pyrazole derivatives exhibit significant insecticidal properties. The findings highlight the potential of these compounds in the development of innovative insecticides, paving the way for future research in pest control strategies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
- Date Crossref
- 23/01/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Women University Multan Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Islamia College University Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Government College University Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Khwaja Fareed University of Engineering and Information Technology Department of Agricultural Engineering pays non établi dans la noticeUniversité ou école supérieure
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King Saud University pays non établi dans la noticeUniversité ou école supérieure
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Government Sadiq College Women University Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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University of Sargodha Institute of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Medical University of Sofia pays non établi dans la noticeUniversité ou école supérieure
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College of Pharmacy Department of Pharmaceutics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmaceutical Chemistry pays non établi dans la noticeUniversité ou école supérieure
Department of Chemistry — The Women University Multan, Department of Chemistry — Islamia College University et Department of Chemistry — Government College University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.