Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: Mechanism studies have indicated that magnesium (Mg) and calcium (Ca) have important biological functions in glucose regulation, but epidemiological data on their associations with glycosylated hemoglobin (HbA1c) are sparse. We aimed to explore the associations of Mg and Ca with abnormal HbA1c, and examine the mediating effects of inflammation in coronary artery disease (CAD) Chinese adults. METHODS AND STUDY DESIGN: A hospital-based cross-sectional study of 11934 patients with CAD was conducted. Serum Mg and Ca concentrations were measured. RESULTS: In multivariable analyses, Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c (Q4 vs Q1: ORMg: 0.61, 95% CIMg: 0.53, 0.71; ORMg/Ca ratio: 0.67, 95% CIMg/Ca ratio: 0.54, 0.84). However, null association of Ca with abnormal HbA1c was shown (Q4 vs Q1: OR: 1.15, 95% CI: 0.92, 1.44). Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose (FBG). In contrast, serum Ca was positively associated with abnormal FBG. Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein (hsCRP) on Mg and Mg/Ca-abnormal HbA1c associations. CONCLUSIONS: Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c in Chinese adults with CAD. The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.
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Nantong University Department of Child Healthcare and Scientific Education Section pays non établi dans la noticeUniversité ou école supérieure
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Nantong Maternity and Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Capital Medical University Department of Psycho-Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Beijing Anzhen Hospital pays non établi dans la noticeÉtablissement de santé
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Wuhan University pays non établi dans la noticeUniversité ou école supérieure
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Wuhan Asia Heart Hospital Image Center pays non établi dans la noticeÉtablissement de santé
Department of Child Healthcare and Scientific Education Section — Nantong University, Nantong Maternity and Child Health Hospital et Department of Psycho-Cardiology — Capital Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.