Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities

Le résumé fourni par la source

Novel natural nanomaterials are extensively investigated nowadays due to their potential biological activities and low toxicity. In the present investigation, polyvinyl alcohol was used as a green reducing agent to synthesize Plumeria rubra nanoparticles. Plumeria rubra flowers were collected and extracted using a Soxhlet apparatus and examined through gas and liquid chromatography which revealed the presence of palmitic acid, linoleic acid, N-(O-Nitrophenylthio)-l-leucine, plumieridin B, lupeol, and rutin. The antimicrobial activity of the flower extract showed MIC values between 15.6 and 250.0 μg/mL. The optimum conditions for Plumeria rubra nanoparticle synthesis were 30 min stirring time and a 1:1 PVA/ Plumeria rubra ratio. The optimized nanoparticles showed antimicrobial activity reached 7.8 μg/mL with entrapment and loading efficiencies %, zeta size, zeta potential, and PDI were 89.0 %, 40.0 %, 18.5 nm, −1.65 mV, and 0.29, respectively. The cytotoxic effect (IC 50 ) of Plumeria rubra nanoparticles reached 503.2 μg/mL. Plumeria rubra nanoparticles showed low antiviral activity against 229E (low-pathogenic coronavirus), with selectivity index 2.90. Moreover, the synthesized Plumeria rubra nanoparticles' anti-inflammatory effect showed effective and selective COX-2 inhibition (IC 50 = 4.2 μM, SI = 15.57). On top of that, the synthesized nanoparticles reduced the parasitic tachyzoites' count by 37, 43, and 49 % in the spleen, brain, and liver, respectively.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.