Quantifying conjugation rates in clinical and environmental matrices: a systematic review to inform risk assessment
Rattachement africain : us, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Antimicrobial resistance (AMR) has become a major public health concern and challenge. The transfer of antimicrobial resistance genes (ARG) between bacteria and the movement of antibiotic resistant bacteria (ARB) between human, environmental, and animal reservoirs allows AMR to spread and drive its persistence. Modeling efforts are useful for providing understanding of fate and transport, dynamics, or probabilistic risk, but lack estimates of bacterial conjugation parameters to be used within these frameworks. Methods: A systematic literature review was conducted to summarize measured rates of conjugation for AMR and other resistances across a variety of settings, experimental media, and donor sources. Results: Across the 113 studies, reported conjugation frequencies and rates were examined in environmental, clinical, and animal/agricultural settings. The findings spanned over 12 orders of magnitude. From all studies, a subset of 25 were able to be analyzed for time-dependent rate estimation, which is most useful in modeling approaches. The highest rates were found in samples originating from wastewater sources or transferred in wastewater matrices, pointing to the significance and role of anthropogenic impacts on the environment in dissemination of AMR. Discussion: The results allowed us to identify knowledge gaps in measuring conjugation rates in key environmental exposure areas, such as biofilms, and in reporting experimental outputs for understanding cell growth and conjugation dynamics, such as donor, recipient and transconjugant densities over time.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Quantifying conjugation rates in clinical and environmental matrices: a systematic review to inform risk assessment
- Date Crossref
- 17/01/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Center for Environmental Health pays non établi dans la noticeStructure de recherche
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Arizona State University The Biodesign Center for Environmental Health Engineering pays non établi dans la noticeUniversité ou école supérieure
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Barnard College Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
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Medical Research Council pays non établi dans la noticeOrganisme public
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University of Rochester Department of Chemical Engineering pays non établi dans la noticeUniversité ou école supérieure
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School of Sustainable Engineering and the Built Environment pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Jameel Institute pays non établi dans la noticeUniversité ou école supérieure
Center for Environmental Health, The Biodesign Center for Environmental Health Engineering — Arizona State University et Department of Biology — Barnard College, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.