MPOX A - GLOBAL PUBLIC HEALTH THREAT

Le résumé fourni par la source

Mpox also known as monkeypox, is a zoonotic viral disease instigated by the Mpox virus, a double-stranded DNA virusrelated to smallpox. The disease typically presents with flu-like symptoms and a characteristic rash that progresses through distinctstages, including painful lesions and scabs. Two recognized clades, Clade I and Clade II, show regional prevalence in Central andEast Africa, respectively, with varying severity and mortality rates. Efforts to combat Mpox include targeted vaccinations, such asMVA-BN and LC16, prioritized for high-risk groups and regions. Recent research advances have identified G-quadruplex structureswithin the viral genome, enabling more precise diagnostic tools using fluorescent probes. Countries have implemented diversestrategies to curb Mpox spread, including intensified screening of travelers, enhanced laboratory diagnostics, and public healthcampaigns. While nations like the Democratic Republic of Congo (DRC) face severe outbreaks, others such as Indonesia, China,and Kenya emphasize rigorous surveillance and border controls. The evolving epidemic highlights the critical need for internationalcollaboration, rapid diagnostic innovation, and equitable vaccine distribution to mitigate the global impact of Mpox. This review onMpox (formerly monkeypox) should comprehensively address its recent epidemiology, including global incident trends, outbreakhotspots, and the factors driving its spread and explore vaccination efforts, focusing on the efficacy and availability of smallpoxbasedvaccines used against Mpox. Recent advancements in diagnostics, including novel detection methods like rapid molecularassays, should be highlighted. The review examines preventive measures undertaken by affected countries, such as contact tracing,isolation protocols, and public health campaigns.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.