From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes
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Le résumé fourni par la source
The aim of the circular economy is to treat waste as a valuable raw material, reintegrating it into the industrial economy and extending the lifecycle of subsequent products. Efforts to reduce the production of hard-to-recycle waste are becoming increasingly important to manufacturers, not only of consumer goods but also of specialized items that are difficult to manufacture, such as medical supplies, which have now become a priority for the European Union. The purpose of the study is to manufacture a novel human-purified type I collagen membrane from bone remnants typically discarded during the processing of cortico-cancellous bones in tissue banks and to evaluate its mechanical properties and effectiveness in regenerating bone-critical mandibular defects in rabbits. To prepare the novel membrane, cortico-cancellous bone chip samples from a local tissue bank were processed to isolate collagen by demineralization under agitation in HCl, cast into a silicone mold, and air-dried at room temperature and UV irradiation. The average thickness of the four batches analyzed by SEM was 37.3 μm. The average value of Young's modulus and tensile strength obtained from the specimens was 2.56 GPa and 65.43 Mpa, respectively. The membrane's efficacy was tested by creating a critical bicortical and bilateral osteoperiosteal defect in rabbit mandibles. The right-side defects were covered with the collagen membrane, while the left-side defects were left untreated as a control. Nine weeks post-surgery, clinical, radiological, and histological analyses demonstrated new bone formation in the treated areas, whereas the control sites showed no bone regeneration. This innovative approach not only contributes to sustainability in healthcare by optimizing biological waste but also exemplifies efficient resource use in line with the circular economy, offering a cost-effective, biocompatible option that could benefit national health systems.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes
- Date Crossref
- 15/01/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hospital Universitario De Cabueñes pays non établi dans la noticeÉtablissement de santé
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Universidad de Oviedo pays non établi dans la noticeUniversité ou école supérieure
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Hospital Universitario Central de Asturias pays non établi dans la noticeÉtablissement de santé
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Gobierno del Principado de Asturias pays non établi dans la noticeOrganisme public
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Instituto de Salud Carlos III pays non établi dans la noticeOrganisation à but non lucratif
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Centre for Biomedical Network Research on Rare Diseases pays non établi dans la noticeStructure de recherche
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Cabueñes University Hospital Oral and Maxillofacial Surgery Service pays non établi dans la noticeUniversité ou école supérieure
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Central University Hospital of Asturias Department of Surgery and Specialties pays non établi dans la noticeUniversité ou école supérieure
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Carlos III Health Institute (ISCIII) Biomedical Research Networking Center on Rare Diseases (CIBERER) pays non établi dans la noticeStructure de recherche
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University of Oviedo Health Research Institute of the Principality of Asturias (ISPA) pays non établi dans la noticeUniversité ou école supérieure
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Tissue Engineering Unit pays non établi dans la noticeInstitution
Hospital Universitario De Cabueñes, Universidad de Oviedo et Hospital Universitario Central de Asturias, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.