Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots
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Le résumé fourni par la source
A novel electrochemical detection method utilizing a cost-effective hybrid-modified electrode has been established. A glassy carbon (GC) modified electrode was tested for its ability to measure electrochemical tTG antibody levels, which are essential for diagnosing and monitoring Celiac disease (CD). Tissue transglutaminase protein biomolecules are immobilized on a quantum dots-polypyrrole nanocomposite in the improved electrode. Initial, quantum dots (QDs) were obtained from Bombyx mori silk fibroin and embedded in polypyrrole film. Using carbodiimide coupling, a polyamidoamine (PAMAM) dendrimer was linked with GQDs-polypyrrole film to improve sensor sensitivity. The tissue transglutaminase (tTG) antigen was cross-linked onto PAMAM using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)-N-hydroxy succinimide (NHS) chemistry to develop a nanoprobe that can detect human serum anti-tTG antibodies. The physicochemical characteristics of the synthesized nanocomposite were examined by FTIR, UV-visible, FE-SEM, EDX, and electrochemical studies. The novel electrode measures anti-tissue antibody levels in real time using human blood serum samples. The modified electrode has great repeatability and an 8.7 U/mL detection limit. Serum samples from healthy people and CD patients were compared to standard ELISA kit assays. SPSS and Excel were used for statistical analysis. The improved electrode and detection system can identify anti-tissue antibodies up to 80 U/mL.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots
- Date Crossref
- 13/01/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universitatea Națională de Știință și Tehnologie Politehnica București pays non établi dans la noticeUniversité ou école supérieure
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Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu" pays non établi dans la noticeÉtablissement de santé
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Faculty of Applied Chemistry and Materials Science pays non établi dans la noticeUniversité ou école supérieure
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National Institute for Mother and Child Health “Alessandrescu-Rusescu” pays non établi dans la noticeStructure de recherche
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National Institute for Mother and Child Health "Alessandrescu-Rusescu" pays non établi dans la noticeStructure de recherche
Universitatea Națională de Știință și Tehnologie Politehnica București, Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu" et Faculty of Applied Chemistry and Materials Science, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.