Cyclic α‐/β‐Peptoids: Bioinspired Macrocyclic Peptidomimetics

Le résumé fourni par la source

Abstract Peptoid‐based macrocycles represent precious tools in biomimetic and supramolecular chemistry for their innate propensity to recognize biopolymers, molecules, and ion guests, and also for their impressive ability to adopt stable secondary structures and display remarkable chemical diversity. The ample variety of N ‐substituted glycine available, the subtle host/guest interplay, and the efficient head‐to‐tail macrocyclization reactions greatly expand their potentials and functional capabilities. In this chapter, we report studies correlating sequence, structures, and functions of α‐/β‐cyclic peptoids reported in the chemical literature till 2021 and describe how crucial intramolecular interactions, cationic hosts, and strategically positioned stereogenic centers forge their morphologic attributes. The advances in the field of cyclic peptoids represent the first steps for the foundations of a rational design of protein mimetics and a possible model on which to base drug design and supramolecular/biomimetic chemistry.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.