A nomogram based on InLDH and InNLR for predicting disseminated intravascular coagulation in patients with heat stroke
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Le résumé fourni par la source
Background: Heat stroke (HS), a potentially fatal heat-related illness, is often accompanied by disseminated intravascular coagulation (DIC) early, resulting in a poorer prognosis. Unfortunately, diagnosis by current DIC scores is often too late to identify DIC. This study aims to investigate the predictors and predictive model of DIC in HS to identify DIC early. Methods: This retrospective study analyzed clinical data of patients with HS in a tertiary hospital from January 1, 2008 to December 31, 2020. Univariate and multivariate logistic regression analyses were employed to identify the risk factors for DIC in HS. The predictive models based on these risk factors were constructed and externally validated, and their predictive efficacy was evaluated using receiver operating characteristic curves. Results: A total of 219 HS patients, including 49 with DIC, were included. The independent risk factors for DIC were identified as follows: neutrophil percentage (Neu%), lymphocyte count, lymphocyte percentage (Lym%), creatine kinase-MB (CKMB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), neutrophil–lymphocyte ratio (NLR), monocyte–lymphocyte ratio (MLR), and rhabdomyolysis (RM). After logarithmization, the final predictive model based on the logarithm of lactate dehydrogenase (InLDH; odds ratio (OR) = 9.266, 95% confidence interval (95%CI; 4.379–19.607), p < 0.0001) and the logarithm of neutrophil–lymphocyte ratio (InNLR; OR = 3.393, 95%CI (1.834–6.277), p < 0.0001) was constructed with the largest area under the curve (0.928). A nomogram incorporating InLDH and InNLR was developed and showed excellent discrimination and calibration capabilities. Conclusion: Nine independent risk factors were identified for the occurrence of DIC in HS patients. The predictive model based on InLDH and InNLR can effectively predict the incidence of DIC. A nomogram based on InLDH and InNLR was developed to facilitate early identification and timely treatment of DIC in HS patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A nomogram based on InLDH and InNLR for predicting disseminated intravascular coagulation in patients with heat stroke
- Date Crossref
- 01/01/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Longgang Central Hospital Department of Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Guangdong Pharmaceutical University pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Southern Medical University pays non établi dans la noticeÉtablissement de santé
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Guangzhou University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Southern Medical University pays non établi dans la noticeUniversité ou école supérieure
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General Hospital of Southern Theatre Command of PLA Department of Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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The First School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Intensive Care Unit — Longgang Central Hospital, Guangdong Pharmaceutical University et Third Affiliated Hospital of Southern Medical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.