Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis
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Le résumé fourni par la source
Introduction: Acute respiratory distress syndrome (ARDS) is a life-threatening type of acute lung injury (ALI) characterized by elevated mortality rates and long-term effects. To date, no pharmacological treatment has proven effective for ARDS. Mesenchymal stem cell-derived apoptotic vesicles (apoVs) were recently found to have excellent therapeutic potential for inflammatory diseases. In this study, our aim was to investigate the therapeutic effects and underlying mechanisms of apoVs in ALI. Methods: ALI was induced in mice through intratracheal instillation of lipopolysaccharide (LPS). ApoVs were then administered two hours post-induction, and their impacts on platelet activation, neutrophil infiltration, and NETosis were assessed. Additionally, the role of CD73 in mediating these effects was thoroughly investigated. Results: ApoVs inhibit platelet activation, thereby impeding the infiltration of neutrophils into the lung and the initiation of NETosis, ultimately alleviating ALI. Remarkably, apoVs were enriched with CD73, which was critical for apoV-mediated repression of platelet activation and neutrophil NETosis, as well as the therapeutic effects observed in lung injury. Conclusion: This study reveals that apoVs inhibit platelet activity and neutrophil NETosis via CD73, offering an innovative and effective cell-free therapeutic strategy for ALI/ARDS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis
- Date Crossref
- 01/01/2025
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sun Yat-sen University pays non établi dans la noticeUniversité ou école supérieure
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Stomatology Hospital Department of Orthodontics pays non établi dans la noticeÉtablissement de santé
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Cell Technology (China) pays non établi dans la noticeEntreprise
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Guangzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Provincial Key Laboratory of Stomatology pays non établi dans la noticeStructure de recherche
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Guanghua School of Stomatology Hospital of Stomatology pays non établi dans la noticeUniversité ou école supérieure
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South China Center of Craniofacial Stem Cell Research pays non établi dans la noticeInstitution
Sun Yat-sen University, Department of Orthodontics — Stomatology Hospital et Cell Technology (China), avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.