A multimodal neuroimaging study of cerebrovascular regulation: protocols and insights of combining electroencephalography, functional near-infrared spectroscopy, transcranial Doppler ultrasound, and physiological parameters
Rattachement africain : ca, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Objective. The current paper describes the creation of a simultaneous trimodal neuroimaging protocol. The authors detail their methodological design for a subsequent large-scale study, demonstrate the ability to obtain the expected physiologically induced responses across cerebrovascular domains, and describe the pitfalls experienced when developing this approach. Approach. Electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial Doppler ultrasound (TCD) were combined to provide an assessment of neuronal activity, microvascular oxygenation, and upstream artery velocity, respectively. Real-time blood pressure, capnography, and heart rate were quantified to control for the known confounding influence of cardiorespiratory variables. The EEG-fNIRS-TCD protocol was attached to a 21 year-old male who completed neurovascular coupling/functional hyperemia (finger tapping and ‘Where’s Waldo/Wally?’), dynamic cerebral autoregulation (squat-stand maneuvers), and cerebrovascular reactivity tasks (end-tidal clamping during hypocapnia/hypercapnia). Main results. In a pilot participant, the Waldo task produced robust hemodynamic responses within the occipital microvasculature and the posterior cerebral artery. A ∼90% decrease in alpha band power was seen in the occipital cortical region compared between the eyes closed and eyes opened protocol, compared to the frontal, central, and parietal regions (∼80% reduction). A modest increase in motor oxygenated hemoglobin was seen during the finger tapping task, with a harmonious alpha decrease of ∼15% across all cortical regions. No change in the middle or posterior cerebral arteries were noted during finger tapping. During cerebral autoregulatory challenges, sinusoidal oscillations were produced in hemodynamics at 0.05 and 0.10 Hz, while a decrease and increase in TCD and fNIRS metrics were elicited during hypocapnia and hypercapnia protocols, respectively. Significance. All neuroimaging modalities have their inherent limitations; however, these can be minimized by employing multimodal neuroimaging approaches. This EEG-fNIRS-TCD protocol enables a comprehensive assessment of cerebrovascular regulation across the association between electrical activity and cerebral hemodynamics during tasks with a mild degree of body and/or head movement.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A multimodal neuroimaging study of cerebrovascular regulation: protocols and insights of combining electroencephalography, functional near-infrared spectroscopy, transcranial Doppler ultrasound, and physiological parameters
- Date Crossref
- 09/01/2025
- Éditeur
- IOP Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Calgary Alberta Children's Hospital Res*earch Institute pays non établi dans la noticeUniversité ou école supérieure
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Alberta Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Université Bourgogne Franche-Comté pays non établi dans la noticeUniversité ou école supérieure
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Hotchkiss Brain Institute pays non établi dans la noticeUniversité ou école supérieure
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Libin Cardiovascular Institute of Alberta pays non établi dans la noticeStructure de recherche
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Health Sciences Centre pays non établi dans la noticeÉtablissement de santé
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Faculty of Kinesiology Cerebrovascular Concussion Lab pays non établi dans la noticeUniversité ou école supérieure
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Cumming School of Medicine Department of Clinical Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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Atlas Institute for Veterans and Families pays non établi dans la noticeStructure de recherche
Alberta Children's Hospital Res*earch Institute — University of Calgary, Alberta Children's Hospital et Université Bourgogne Franche-Comté, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.