Persistent organic pollutants and endogenous sex-related hormones in Hispanic/Latino adults: The Hispanic Community health study/study of Latinos (HCHS/SOL)
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Le résumé fourni par la source
BACKGROUND: Previous studies have demonstrated associations of persistent organic pollutants (POPs) with sex-related hormones; however, findings were inconsistent. Sex-specific impacts and pathways through which adiposity influences associations are not completely understood. We sought to evaluate sex-specific associations of POPs serum concentration with sex-related hormones and to explore pathways through which adiposity may modify associations. METHODS: We studied 1073 men and 716 postmenopausal women participating in the "Persistent Organic Pollutants, Endogenous Hormones, and Diabetes in Latinos" ancillary study which is a subcohort of the "Hispanic Community Health Study/Study of Latinos." We use baseline examination data collected from 2008 to 2011 to investigate associations between eight organochlorine pesticides (OCPs), five polychlorinated biphenyls (PCB) groups, sum of polybrominated diphenyl ethers and polybrominated biphenyl 153 on sex hormone binding globulin (SHBG) and various sex-related hormone levels. We examined associations cross-sectionally using linear and logistic regression models adjusted for complex survey design and confounders. RESULTS: PCBs and select OCPs were associated with increased SHBG in women and decreased estradiol (E2) and/or bioavailable E2 in men. For instance, per quartile increase in serum concentrations of ∑PCBs and oxychlordane were associated with decreased levels of E2 (β = -6.36 pmol/L; 95% CI: 10.7,-2.02 and β = -5.08 pmol/L; 95% CI: 8.11,-2.05) and bioavailable E2 (β = -4.48 pmol/L; 95% CI: 7.22,-1.73 and β = -4.23 pmol/L; 95% CI: 6.17,-2.28), respectively, in men, and increased levels of SHBG (β = 7.25 nmol/L; 95% CI:2.02,12.8 and β = 9.42 nmol/L; 95% CI:4.08,15.0), respectively, in women. p,p'-DDT and β-HCCH, and o,p'-DDT were also associated with decreased testosterone (T) and bioavailable T (ng/dL) levels in men. Adiposity modified associations in men, revealing stronger inverse associations of PCBs, PBDEs, and several OCPs with LH, SHBG, E2, bioavailable E2, T, and the ratios of LH to FSH and E2 to T in those with below median body mass index and waist-to-hip ratio. CONCLUSION: Distinct patterns of hormone dysregulation with increasing POPs serum concentration were identified in men and post-menopausal women. In men but less so in postmenopausal women, adiposity modified associations of POPs serum concentration with sex-related hormones.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Persistent organic pollutants and endogenous sex-related hormones in Hispanic/Latino adults: The Hispanic Community health study/study of Latinos (HCHS/SOL)
- Date Crossref
- 01/02/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chicago Department of Public Health pays non établi dans la noticeOrganisme public
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University of Illinois Chicago Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Urbana-Champaign pays non établi dans la noticeUniversité ou école supérieure
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Jesse Brown VA Medical Center pays non établi dans la noticeÉtablissement de santé
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Office of Minority Health pays non établi dans la noticeInstitution
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University of North Carolina at Chapel Hill Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Albert Einstein College of Medicine Department of Epidemiology and Population Health pays non établi dans la noticeUniversité ou école supérieure
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San Diego State University Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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University of Minnesota Department of Laboratory Medicine and Pathology pays non établi dans la noticeUniversité ou école supérieure
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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School of Public Health Division of Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Persistent Pollutants Biomonitoring Laboratory pays non établi dans la noticeStructure de recherche
Chicago Department of Public Health, Department of Medicine — University of Illinois Chicago et University of Illinois Urbana-Champaign, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.