Prediction of good neurological outcome after return of circulation following paediatric cardiac arrest: A systematic review and meta-analysis
Rattachement africain : ca, gb, br, us, au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIM: To evaluate the ability of blood-biomarkers, clinical examination, electrophysiology, or neuroimaging, assessed within 14 days from return of circulation to predict good neurological outcome in children following out- or in-hospital cardiac arrest. METHODS: Medline, EMBASE and Cochrane Trials databases were searched (2010-2023). Sensitivity and false positive rates (FPR) for good neurological outcome (defined as either 'no, mild, moderate disability or minimal change from baseline') in paediatric survivors were calculated for each predictor. Risk of bias was assessed using the QUIPS tool. RESULTS: Thirty-five studies (2974 children) were included. The presence of any of the following had a FPR < 30% for predicting good neurological outcome with moderate (50-75%) or high (>75%) sensitivity: bilateral reactive pupillary light response within 12 h; motor component ≥ 4 on the Glasgow Coma Scale score at 6 h; bilateral somatosensory evoked potentials at 24-72 h; sleep spindles, and continuous cortical activity on electroencephalography within 24 h; or a normal brain MRI at 4-6d. Early (≤12 h) normal lactate levels (<2mmol/L) or normal s100b, NSE or MBP levels predicted good neurological outcome with FPR rate < 30% and low (<50%) sensitivity. All studies had moderate to high risk of bias with timing of measurement, definition of test, use of multi-modal tests, or outcome assessment heterogeneity. CONCLUSIONS: Clinical examination, electrophysiology, neuroimaging or blood-biomarkers as individual tests can predict good neurological outcome after cardiac arrest in children. However, evidence is often low quality and studies are heterogeneous. Use of a standardised, multimodal, prognostic algorithm should be studied and is likely of added value over single modality testing.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prediction of good neurological outcome after return of circulation following paediatric cardiac arrest: A systematic review and meta-analysis
- Date Crossref
- 01/02/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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SickKids Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Western University pays non établi dans la noticeUniversité ou école supérieure
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London Health Sciences Centre pays non établi dans la noticeÉtablissement de santé
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Birmingham Women’s and Children’s NHS Foundation Trust Paediatric Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo pays non établi dans la noticeÉtablissement de santé
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Children's Hospital of Philadelphia pays non établi dans la noticeOrganisme public
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University of Iowa pays non établi dans la noticeUniversité ou école supérieure
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Children's Health Queensland Hospital and Health Service pays non établi dans la noticeÉtablissement de santé
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Hospital for Sick Children pays non établi dans la noticeÉtablissement de santé
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University of Toronto Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Mental Health Research Canada pays non établi dans la noticeOrganisation à but non lucratif
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University of Pennsylvania Perelman School of Medicine The Children's Hospital of Philadelphia pays non établi dans la noticeUniversité ou école supérieure
SickKids Foundation, Western University et London Health Sciences Centre, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.