Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
This review highlights the significance of the Japan Diabetes Complications Study (JDCS), one of the earliest large-scale studies of people with type 2 diabetes outside Europe and the United States, in understanding type 2 diabetes mellitus among East Asian populations, particularly in Japan. Historically, large-scale clinical studies on type 2 diabetes mellitus have predominantly focused on Western populations, despite East Asians comprising the largest proportion of diabetic patients globally. The JDCS, which was initiated in 1996, enrolled 2,033 Japanese type 2 diabetes mellitus patients. It aimed to evaluate the effects of intensive lifestyle interventions on diabetic complications. The study demonstrated that lifestyle-focused interventions significantly reduced the risk of stroke and other complications compared to conventional treatment. Key findings of its sub-analyses include the unique characteristics of Japanese patients with type 2 diabetes mellitus, such as their lower body mass index (BMI) compared to Western counterparts and a stronger association between even modest BMI increases and beta cell dysfunction. Additionally, the JDCS provided insights into the risk factors for nephropathy, retinopathy, and macrovascular complications, emphasizing the importance of controlling blood pressure, glycemia, and lifestyle factors. The study also explored the impact of diet, exercise, and mental health on diabetic outcomes, revealing the protective effects of physical activity and a balanced diet, while highlighting the risks associated with high salt intake and depression. A risk prediction model tailored to Japanese patients was also developed. Overall, this study made a significant contribution to the evidence-based management of type 2 diabetes mellitus in East Asia.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes
- Date Crossref
- 24/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Niigata University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
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University of Niigata Prefecture Department of Health and Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Kobe Pharmaceutical University pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Kitasato University Health Care Center pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Metropolitan Geriatric Hospital pays non établi dans la noticeÉtablissement de santé
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Kyoto University Department of Clinical Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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The Institute of Medical Science pays non établi dans la noticeInstitution
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Laboratory of Epidemiology and Prevention Kobe Pharmeceutical University Kobe Japan Laboratory of Epidemiology and Prevention pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medicine Osaka University Osaka Japan Department of Social Medicine pays non établi dans la noticeUniversité ou école supérieure
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and Endocrinology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan Department of Diabetes pays non établi dans la noticeStructure de recherche
Department of Hematology — Niigata University, Department of Health and Nutrition — University of Niigata Prefecture et Kobe Pharmaceutical University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.