Hepatoprotective efficacy of low molecular weight chicken intestine peptide against acute alcohol-induced liver injury
Rattachement africain : cn, mo. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Food-derived bioactive peptides exhibit good health-promoting effects. In this study, low molecular weight chicken intestine peptide (CIP) below 2 kDa is prepared through trypsin hydrolysis of chicken intestine and ultrafiltration, and the hepatoprotective effects of CIP and underlying mechanisms were investigated. Our findings indicated that CIP alleviated acute liver injury induced by alcohol in mice. Because of iron chelating properties and free radical scavenging activities, CIP inhibited the overload of free iron and the accumulation of lipid peroxides in liver tissues, thereby suppressing alcohol-induced ferroptosis of hepatocytes. In vitro studies demonstrated that CIP suppressed lipid peroxidation and subsequent ferroptosis of HepG2 cells induced by hydrogen peroxide. Mechanistic studies further revealed that CIP promoted the expression and activation of nuclear factor erythroid 2-related factor 2 (NRF2), leading to the increased transcription of antioxidant response elements and solute carrier family 7 member 11 (SLC7A11). This promoted the synthesis of glutathione and enhanced the enzyme activity of glutathione peroxidase 4 (GPX4), facilitating the clearance of lipid peroxides. These findings suggest that CIP holds promise for the prevention and treatment of alcoholic liver disease and other oxidative stress-related liver diseases.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hepatoprotective efficacy of low molecular weight chicken intestine peptide against acute alcohol-induced liver injury
- Date Crossref
- 01/12/2025
- Éditeur
- Tsinghua University Press
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jinan University Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility pays non établi dans la noticeUniversité ou école supérieure
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Beijing University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Yunnan University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Macau University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines pays non établi dans la noticeUniversité ou école supérieure
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State Administration of Traditional Chinese Medicine of the People's Republic of China pays non établi dans la noticeOrganisme public
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School of Chinese Materia Medica pays non établi dans la noticeUniversité ou école supérieure
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Ltd. Springsnow Food Group Co. pays non établi dans la noticeEntreprise
Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility — Jinan University, Beijing University of Chinese Medicine et Yunnan University of Traditional Chinese Medicine, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.