电化学碘参与的P-H/N-H偶联反应

Le résumé fourni par la source

P–N bond formation plays an important role in the synthesis of natural drug molecules, bioactive molecules, ligands and catalysts. The traditional P–N bonding reaction is mainly limited to Staudinger condensation or nucleophilic substitution of phosphine halides with amines, which limits its application in organic synthesis. Therefore, it is of great significance to develop a green, mild and efficient synthesis method for P–N compounds. In this paper, we report the direct construction of P–N bonds under mild conditions using aryl/alkoxyl phosphine oxides P–H and N–H compounds through iodine-involved electrochemical oxidation-reduction by paired electrolysis method, and with good substrate compatibility. Thus, the efficient amination reactions of various phosphine-containing compounds were realized, which provided a new way for the synthesis of compounds containing P–N bonds.

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