Associations of Combined Genetic and Lifestyle Risks With Incident Type 2 Diabetes in the UK Biobank
Rattachement africain : us, de, jp, gb, cn, kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Type 2 diabetes (T2D) results from a complex interplay between genetic predisposition and lifestyle factors. Both genetic susceptibility and unhealthy lifestyle are known to be associated with elevated T2D risk. However, their combined effects on T2D risk are not well studied. We aimed to determine whether unhealthy modifiable health behaviors were associated with similar increases in the risk of incident T2D among individuals with different levels of genetic risk. Methods: We performed a genetic risk score (GRS) by lifestyle interaction analysis within 332,251 non-diabetic individuals at baseline from the UK Biobank. Multi-ancestry GRS were calculated by summing the effects of 783 T2D-associated variants and ranked into tertiles. We used baseline self-reported data on smoking, BMI, physical activity level, and diet quality to categorize participants as having a healthy, intermediate, or unhealthy lifestyle. Cox proportional hazards regression models were used to generate adjusted hazards ratios (HR) of T2D risk and associated 95% confidence intervals (CI). Results: < 0.001) were independently associated with increased risk for T2D. Compared with healthy lifestyle, unhealthy lifestyle was associated with increased T2D risk in all genetic risk strata, with adjusted HR ranging from 7.11 (low genetic risk) to 16.33 (high genetic risk). Conclusions: High genetic risk and unhealthy lifestyle were the most significant contributors to the development of T2D. Individuals at all levels of genetic risk can greatly mitigate their risk for T2D through lifestyle modifications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations of Combined Genetic and Lifestyle Risks With Incident Type 2 Diabetes in the UK Biobank
- Date Crossref
- 20/04/2026
- Éditeur
- American Diabetes Association
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Massachusetts Amherst Department of Biostatistics and Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Helmholtz Munich pays non établi dans la noticeStructure de recherche
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Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
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Broad Institute Programs in Metabolism and Medical and Population Genetics pays non établi dans la noticeOrganisation à but non lucratif
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Massachusetts General Hospital Diabetes Unit and Center for Genomic Medicine pays non établi dans la noticeÉtablissement de santé
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University of Pennsylvania Graduate Program in Genomics and Computational Biology pays non établi dans la noticeUniversité ou école supérieure
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Amherst College pays non établi dans la noticeUniversité ou école supérieure
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The University of Tokyo pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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National Institutes of Health pays non établi dans la noticeOrganisme public
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University of Cambridge Department of Public Health and Primary Care pays non établi dans la noticeUniversité ou école supérieure
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National Human Genome Research Institute Center for Precision Health Research pays non établi dans la noticeStructure de recherche
Department of Biostatistics and Epidemiology — University of Massachusetts Amherst, Helmholtz Munich et Technical University of Munich, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.