Acute kidney injury with hypernatremia and major adverse kidney events
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Le résumé fourni par la source
ABSTRACT Introduction Consequences of hypernatremia in akute kidney injury (AKI-hyperNa) is poorly understood. We analyzed the risk of major adverse kidney events (MAKE) in comparison with AKI and normal serum sodium (AKI-normalNa). Such data could help in understanding this complex interaction. Methods In this retrospective cohort we compared the AKI-hyperNa with the AKI-normalNa regarding the risk of MAKE, which include death, new dialysis requirement, and worsening kidney function (≥25% decrease in estimated glomerular filtration rate), at 10 (MAKE10) and at 30–90 days (MAKE30–90) using multivariate logistic regression and area under the curve (AUC) analysis. The association between serum sodium levels (per 1 mEq/l increase) and the number of days with hypernatremia was also compared. Results A total of 357 patients were included (78 with AKI-hyperNa and 279 with AKI-normalNa). Compared to the AKI-normalNa, AKI-hyperNa were predominantly male (73% versus 59%), experienced hypernatremia for a longer duration (3 days versus 0 days), and took 5 days to normalize serum sodium levels. After multivariate regression analysis, the AKI-hyperNa group had higher risk of MAKE10 [odds ratio (OR) 5.7, confidence interval (CI) 2.5 to 12.89, p < 0.001] with an AUC of 0.79. Also its components such as mortality and decreased estimated glomerular filtration rate (OR 2.13, CI 1.11 to 4.07, p = 0.021 and OR 20.14, CI 7.69 to 10.03, p = 0.001, respectively). A similar trend was found for MAKE30–90 (OR 4.17, CI 1.73 to 10.03, p ≤ 0.001). A gradual increase in serum sodium was associated with a higher risk of MAKE (OR 1.07, CI 1.04 to 1.11, p ≤ 0.001), as was the number of days spend with hypernatremia (OR 1.51, CI 1.22 to 1.87, p = 0.001). Conclusions In this cohort, AKI-hyperNa compared with AKI-normalNa had a fivefold risk of short- and long-term MAKE. This event was more frequently observed as serum sodium increased and it was closely related to the number of days that hypernatremia persisted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Acute kidney injury with hypernatremia and major adverse kidney events
- Date Crossref
- 18/12/2024
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto Tecnológico de Querétaro pays non établi dans la noticeUniversité ou école supérieure
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Universidad de Guadalajara pays non établi dans la noticeUniversité ou école supérieure
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Hospital Civil de Guadalajara Nephrology Service pays non établi dans la noticeÉtablissement de santé
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Universidad Mayor de San Simón pays non établi dans la noticeUniversité ou école supérieure
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Hospital H+ Queretaro Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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University of Guadalajara Health Sciences Center pays non établi dans la noticeUniversité ou école supérieure
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Hospital Obrero No. 2 – Caja Nacional de Salud Division of Nephrology pays non établi dans la noticeÉtablissement de santé
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IIBISMED pays non établi dans la noticeInstitution
Instituto Tecnológico de Querétaro, Universidad de Guadalajara et Nephrology Service — Hospital Civil de Guadalajara, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.