Efficient Synthesis of cis,cis-Muconic Acid by Catechol Oxidation of Ozone in the Presence of a Base

Le résumé fourni par la source

Muconic acid, a crucial precursor in synthesizing materials like PET bottles and nylon, is pivotal for the anticipated growth in textiles and plastics industries. This study presents a novel chemical synthesis route for cis,cis-muconic acid (ccMA) using catechol. Biochemical methods face scale-up challenges due to microorganism sensitivity and complex extraction processes, while chemical methods involve environmentally harmful substances and have low yields. Our research intro-duces a method that enhances ccMA yield to 56% by employing ozonation in the presence of a hydrophilic base, significantly simplifying the synthesis process. This one-step synthesis reduces reagent use and labor, aligns with green chemistry principles, and avoids using toxic chemicals. The methodology, involving low-temperature ozonation of catechol with base addition, reduces ccMA degradation and improves yield, confirmed by HPLC analysis and replicated experiments. This promising approach could lead to sustainable industrial synthesis of muconic acid deriva-tives. Further investigations will focus on refining this method for larger-scale applications and testing its economic viability, aiming to optimize conditions for maximum efficiency and yield.

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