Improving the Accuracy of Bone-scintigraphy Imaging Analysis Using the Skeletal Count Index: A Study Based on Human Trial Data

Le résumé fourni par la source

The image quality index for whole-body bone scintigraphy has traditionally relied on the total count (Total-C) with a threshold of ≥1.5 mc. However, Total-C measurements are susceptible to variability owing to urine retention. This study aimed to develop a skeletal count (Skel-C)-based index, focusing exclusively on bone regions, to improve the accuracy of image analysis in bone scintigraphy. All cases included herein were Total-C≥1.5 mc. Thresholds were set for Skel-C (0.9–1.2 mc) and Total-C (1.75–2.25 mc); patients were grouped according to whether they were above or below these thresholds. The group including all cases was defined as the Total-C 1.5 high group. Sensitivity and specificity were calculated for each group, and receiver operating characteristic analyses and statistical evaluations were conducted. The specificity of the Skel-C < 0.9 mc group was significantly lower than that of the Skel-C ≥ 0.9 mc group and the Total-C 1.5 high group. These findings highlight the importance of achieving Skel-C ≥ 0.9 mc and suggest that Total-C alone is insufficient for reliable image assessment.

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