CD4 T cell contact drives macrophage cell cycle G0-G1 transition

Résumé fourni par la source

Macrophages are cells implicated in a diverse array of functions such as defence against pathogens, tissue repair /homoeostasis, and anti-cancer activity. 1 , 2 Macrophages are also targets of virus infection, and SAMHD1 is known to restrict lentiviruses through depletion of intracellular dNTP and inhibition of reverse transcription. We previously showed that HIV-1 bypasses this restriction by infecting macrophages that have entered the cell cycle and deactivated SAMHD1 antiviral activity through CDK1 mediated phosphorylation of SAMHD1 at T592. 3

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.