Synergistic efficacy of low-intensity extracorporeal shock wave and platelet-rich plasma on erectile dysfunction
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Erectile dysfunction (ED), an unusual sexual condition in which the person fails to attain or sustain an erectile penis, severely impacts personal relationships, confidence, and efficiency. To date, low-intensity extracorporeal shock wave therapy (Li-ESWT) is an option to manage ED; however, it is associated with adverse events such as bruising, redness, and pain. Hence, in this study, we applied platelet-rich plasma (PRP), a blood-derived biomaterial containing cargo of growth factors, to enhance the therapeutic efficacy of Li-ESWT on ED. We assessed the synergistic effect of PRP+Li-ESWT, in which Li-ESWT was extracorporeally applied simultaneously with PRP. They were evaluated clinically at 22 ± 2, 50 ± 2 and 78 ± 2 days. Statistical analysis was performed using a non-parametric test, Friedman repeated measures as an alternative non-parametric test of ANOVA test. The international index of erectile function (IIEF-5) and erection hardness score (EHS) were recorded. IIEF-5 score in the pre-treated group was 8.36 ± 1.44. After 22 ± 2 days of synergistic PRP+Li-ESWT treatment, the score was 14.45 ± 2.12 (p < 0.028). This score further increased to 15.45 ± 1.93 (p < 0.008) and 16.18 ± 1.48 (p < 0.001) after 50 ± 2 days and 78 ± 2 days of treatment, respectively. The mean pre-treated EHS was 1.64 ± 0.20 (p < 0.002), which increased to 2.81 ± 0.26 (p < 0.002), 3.09 ± 0.25 (p < 0.0002) and 3.18 ± 0.12 (p < 0.000) on day 22 ± 2, 50 ± 2 and 78 ± 2 days, respectively. Conclusively, our study demonstrated potent synergistic therapy of PRP+Li-ESWT in ED treatment by improving IIEF-5 and EHS scores. However, extensive mechanism-based clinical studies are needed to reach a consensus.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synergistic efficacy of low-intensity extracorporeal shock wave and platelet-rich plasma on erectile dysfunction
- Date Crossref
- 01/12/2024
- Éditeur
- Pirogov Russian National Research Medical University
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Taipei Medical University Hospital Nursing Department pays non établi dans la noticeÉtablissement de santé
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Taipei Medical University pays non établi dans la noticeUniversité ou école supérieure
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National Yang Ming Chiao Tung University pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Graduate Institute of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ltd. Victory Biotechnology Co. pays non établi dans la noticeEntreprise
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Baba Kinaram Autonomous State Medical College Chandauli pays non établi dans la noticeUniversité ou école supérieure
Nursing Department — Taipei Medical University Hospital, Taipei Medical University et National Yang Ming Chiao Tung University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.