Endothelin in the Central Nervous System

Le résumé fourni par la source

The identification of endothelin from a porcine aortic endothelial cell culture and its description as a potent and long-acting vasoactive peptide 12 has been rapidly followed by the identification of endothelin isoforms (endothelin-1, endothelin-2, and endothelin-3) and receptor subtypes (ET A , ET B1 , and ET B2 ). In the brain, the presence the endothelin isopeptides and receptor subtypes has been established in various cell types, including neurons, glia, vascular smooth muscle, and endothelium. 34 Consequently, endothelin is no longer viewed strictly as an endothelium-derived peptide. Recent studies suggest that endothelin may exert vascular, paracrine, neuromodulatory, neuroendocrine, and trophic effects in the central nervous system (CNS).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.