Functions Mediated by Peripheral Endothelin Receptors

Le résumé fourni par la source

Endothelin-1, the most potent mammalian vasoconstrictor identified to date, produces contractile responses in vascular smooth muscle that are characteristically long lasting and extremely resistant to washout. 1 In addition to contracting conduit arteries, endothelin-1 also contracts resistance arterioles and venous tissue, the latter possibly being more sensitive to the contractile actions of endothelin-1 than arterial vessels. 2–5 Furthermore, because subthreshold concentrations of endothelin-1 augment the contractile actions of norepinephrine, 5-hydroxytryptamine, and angiotensin n, it has been proposed that endothelin-1 also plays a role in “sensitizing” blood vessels to the actions of other “classical” circulating hormones. 6–8

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.