Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease
Rattachement africain : us, Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Persistent immune activation is linked to elevated cardiovascular diseases in people with HIV on antiretroviral therapy. The fat attenuation index (FAI) is a measure of peri-coronary inflammation that independently predicts cardiovascular disease risk in people without HIV. Whether FAI is associated with immune activation is unknown. METHODS: Peripheral blood T-cell activation and homing phenotypes were measured in people with HIV (n=58) and people without HIV (n=16) without known cardiovascular disease who underwent coronary computed tomography angiography and had FAI measurements. A cross-sectional analysis of an observational cohort was performed. The primary aim was to evaluate associations of T-cell activation and phenotypes with the outcome variables, FAI values of the right coronary artery and left anterior descending artery, which were assessed using multivariable regression models adjusted for age, natal sex, race, low-density lipoprotein cholesterol, body mass index, and use of lipid-lowering medication. RESULTS: T cells from people with HIV showed greater activation, as measured by cluster of differentiation (CD) 38/human leukocyte antigen - DR isotype coexpression on CD4 central memory and terminally-differentiated effector memory subsets and on CD8 effector memory (TEM), than did cells from people without HIV. Expression of the chemokine receptor C-C Chemokine Receptor 2 was reduced on CD4 central memory and TEM and CD8 TEM and terminally-differentiated effector memory subsets in people with HIV. Among all participants, PD-1 (programmed cell death 1) in CD8 central memory was associated with worsened peri-coronary inflammation of the right coronary artery, whereas perforin/granzyme B on CD8 TEM was associated with improved peri-coronary inflammation of the right coronary artery and left anterior descending artery in adjusted analyses. When accounting for HIV serostatus, CD38/human leukocyte antigen - DR isotype coexpression on CD8 central memory, TEM, and terminally-differentiated effector memory cells was associated with more peri-coronary inflammation of the left anterior descending artery. CONCLUSIONS: The associations between T-cell activation with FAI are novel and suggest that T-cell activation may be an important driver of peri-coronary inflammation, occurring at an early stage of atherosclerosis, even before the development of clinical disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease
- Date Crossref
- 01/01/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Case Western Reserve University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Morgan State University pays non établi dans la noticeUniversité ou école supérieure
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Boston University Evans Center for Implementation and Improvement Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Maryland Department of Diagnostic Radiology and Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
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Institute of Human Virology Nigéria (code pays fourni par la source)Organisme public
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Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
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School of Community Health and Policy Department of Statistics pays non établi dans la noticeUniversité ou école supérieure
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Washington University School of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Medicine — Case Western Reserve University, Morgan State University et Evans Center for Implementation and Improvement Sciences — Boston University, avec 5 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.