Subcutaneous and Topical Tranexamic Acid Use During Rhytidectomy
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Le résumé fourni par la source
OBJECTIVE: Tranexamic acid is a potential rhytidectomy adjunct; however, its route of administration, benefits, and safety remain a topic of debate. The purpose of this study is to analyze the effects of topical and subcutaneous TXA during rhytidectomy. METHODS: This is a retrospective, 3-arm analysis of a single surgeon's practice from Aug. 2019 to Nov. 2023. 175 consecutive patients underwent rhytidectomy; 55 did not receive TXA (8/2019-12/2020), 65 received intraoperative topical 25 mg/mL TXA (1/2021-7/2022), and 55 received subcutaneous 5 mg/mL TXA (7/2022-11/2023). Measured outcomes included drain output, bruising, operative time, estimated blood loss, and complications. RESULTS: Subcutaneous and topical TXA had similar drain outputs (11.32 mL vs. 12.98 mL, respectively) and bruising scores (20.93 vs. 22.12, respectively). These were significantly less than the control group (24.05 mL, p < 0.001 and 36.28, p < 0.001, respectively). The subcutaneous group operative time (196.13 min) was less than the topical and control groups (212.72 min, p = 0.01; 207.90 min, p = 0.037, respectively) in patients who underwent rhytidectomy with platysmaplasty. EBL and seroma formation in the subcutaneous TXA group were significantly less than the control (23.92 mL vs. 31.67 mL, p = 0.011; 3.60% vs. 18.18%, p = 0.03, respectively). Hematoma, epidermolysis, and infection rates were similar between all groups. CONCLUSION: Both topical and subcutaneous TXA use during rhytidectomy are associated with reduced postoperative drain output and bruising without an increased risk of complications. Subcutaneous TXA has the added associated benefit of decreasing operative time, EBL, and seroma formation. LEVEL OF EVIDENCE: 3 Laryngoscope, 135:1685-1690, 2025.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Subcutaneous and Topical Tranexamic Acid Use During Rhytidectomy
- Date Crossref
- 06/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin Health pays non établi dans la noticeÉtablissement de santé
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Wisconsin Division of Public Health pays non établi dans la noticeÉtablissement de santé
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Robertson Cosmetic Clinic Middleton Wisconsin U.S.A pays non établi dans la noticeÉtablissement de santé
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University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Department of Surgery University of Wisconsin School of Medicine and Public Health Madision Wisconsin USA pays non établi dans la noticeUniversité ou école supérieure
University of Wisconsin–Madison, University of Wisconsin Health et Wisconsin Division of Public Health, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.