MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features
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Le résumé fourni par la source
OBJECTIVE: Investigate the association between the relative tumor enhancement (RTE) of gadoxetic acid across various MRI phases and immunohistochemical (IHC) features in patients with liver metastases (LM) from colorectal cancer (CRC), breast cancer (BC), and pancreatic cancer (PC). METHODS: A retrospective analysis was conducted on 68 patients with LM who underwent 1.5-T MRI scans. Non-contrast and contrast-enhanced T1-weighted (T1-w) gradient echo (GRE) sequences were acquired before LM biopsy. RTE values among LM groups were compared by cancer type using analysis of variance. The relationships between RTE and IHC features tumor stroma ratio, cell count, Ki67 proliferation index, and CD45 expression were evaluated using Spearman's rank correlation coefficients. RESULTS: Significant differences in RTE were observed across different MRI phases among patients with BCLM, CRCLM, and PCLM: arterial phase (0.75 ± 0.42, 0.37 ± 0.36, and 0.44 ± 0.19), portal venous phase (1.09 ± 0.41, 0.59 ± 0.44, and 0.53 ± 0.24), and venous phase (1.11 ± 0.45, 0.65 ± 0.61, and 0.50 ± 0.20). In CRCLM, RTE inversely correlated with mean Ki67 (r = -0.50, p = 0.01) in the hepatobiliary phase. Negative correlations between RTE and CD45 expression were found in PCLM and CRCLM in the portal venous phase (r = -0.69, p = 0.01 and r = -0.41, p = 0.04) and the venous phase (r = -0.65, p = 0.01 and r = -0.44, p = 0.02). CONCLUSION: Significant variations in RTE were identified among different types of LM, with correlations between RTE values and IHC markers such as CD45 and Ki67 suggesting that RTE may serve as a non-invasive biomarker for predicting IHC features in LM. CRITICAL RELEVANCE STATEMENT: RTE values serve as a predictive biomarker for IHC features in liver metastasis, potentially enhancing non-invasive patient assessment, disease monitoring, and treatment planning. KEY POINTS: Few studies link gadoxetic acid-enhanced MRI with immunohistochemistry in LM. RTE varies by liver metastasis type and correlates with CD45 and Ki67. RTE reflects IHC features in LM, aiding non-invasive assessment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features
- Date Crossref
- 05/12/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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RWTH Aachen University pays non établi dans la noticeUniversité ou école supérieure
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Otto-von-Guericke-Universität Magdeburg pays non établi dans la noticeUniversité ou école supérieure
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Johannes Wesling Klinikum Minden pays non établi dans la noticeÉtablissement de santé
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Ruhr University Bochum pays non établi dans la noticeUniversité ou école supérieure
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University Hospital RWTH Department of Diagnostic and Interventional Radiology pays non établi dans la noticeUniversité ou école supérieure
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University Clinic for Radiology and Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
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Otto-von-Guericke-University Magdeburg Institute of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Johannes Wesling University Institute for Radiology pays non établi dans la noticeUniversité ou école supérieure
RWTH Aachen University, Otto-von-Guericke-Universität Magdeburg et Johannes Wesling Klinikum Minden, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.