NMR ‐based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages
Rattachement africain : cn, ch. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Colorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their distant noncancerous tissues (DNT), to investigate the temporal and spatial heterogeneities of metabolic characterization. Our NMR-based metabolomics fingerprinting revealed that many of the metabolite levels were significantly altered in CCT compared to DNT and esophageal cancer tissues, indicating deregulations of glucose metabolism, one-carbon metabolism, glutamine metabolism, amino acid metabolism, fatty acid metabolism, TCA cycle, choline metabolism, and so forth. A total of five biomarker metabolites, including glucose, glutamate, alanine, valine and histidine, were identified to distinguish between early and advanced stages of CCT. Metabolites that distinguish the different anatomical sites of CCT include glucose, glycerol, glutamine, inositol, succinate, and citrate. Those significant metabolic differences in CRC tissues at different pathological stages and sites suggested temporal and spatial heterogeneities of metabolic characterization in CCT, providing a metabolic foundation for further study on biofluid metabolism in CRC early detection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <scp>NMR</scp> ‐based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages
- Date Crossref
- 04/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Shantou University Radiology Department pays non établi dans la noticeUniversité ou école supérieure
-
Second Affiliated Hospital of Shantou University Medical College pays non établi dans la noticeÉtablissement de santé
-
École Polytechnique Fédérale de Lausanne Animal Imaging and Technology Core pays non établi dans la noticeUniversité ou école supérieure
-
Cancer Hospital of Shantou University Medical College pays non établi dans la noticeÉtablissement de santé
Radiology Department — Shantou University, Second Affiliated Hospital of Shantou University Medical College et Animal Imaging and Technology Core — École Polytechnique Fédérale de Lausanne, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.