Prevalence and clinicopathological characteristics of de novo metastatic cancer at a major radiotherapy centre in West Africa: a cross-sectional study
Rattachement africain : Ghana, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Cancer is a major public health challenge in West Africa, with a significant proportion of cancer-related deaths attributed to distant metastasis. De novo metastatic cancer (DnMC), where metastasis is detected at diagnosis, presents considerable therapeutic challenges, particularly in limited-resource settings where novel treatments are often unavailable and/or unaffordable. Aim: To determine the prevalence, incidence and clinicopathological characteristics of patients diagnosed with DnMC at a major radiotherapy center in West Africa. Methods: This was a single-institution-based quantitative cross-sectional study. Data on the prevalence and incidence of DnMC were retrieved from a hospital-based cancer registry whereas patients' demographic and clinicopathologic data were extracted from patients' medical records and analysed with STATA software (version 16). Descriptive statistics were used to summarise patient- and tumour-related characteristics. Results: The prevalence and incidence of DnMC were 15.2% and 5.3%, respectively, with a 36% overall incidence rate of metastatic cancer. The mean age was 50.9 years (SD 15.2), ranging from 15 to 90 years, with a male-to-female ratio of 1:1.6. Also, 28.8% had a history of alcohol intake whereas 13.7% were (tobacco) smokers. Additionally, 10.3% of the patients had a positive family history of cancer. Pain (28.2%) was the most common presenting symptom, followed by bleeding (16.5%). In all, 34.9% had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 whereas 33.3% were ECOG 1. The gastrointestinal tract (25.8%) and breasts (17.6%) were the most frequent primary cancer sites, whereas 4.4% had metastatic cancers of unknown primary origin. The most frequent sites of distant metastasis were the lungs (34.6%), liver (28.9%) and bone (13.8%). Adenocarcinoma was the most prevalent histological type (35.2%). Conclusion: There was a relatively high rate of DnMC compared with high-income countries, emphasising the need for early detection and expanded access to comprehensive cancer care in limited-resource settings.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and clinicopathological characteristics of de novo metastatic cancer at a major radiotherapy centre in West Africa: a cross-sectional study
- Date Crossref
- 29/11/2024
- Éditeur
- Ecancer Global Foundation
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Korle Bu Teaching Hospital Oncology and Nuclear Medicine Accra, Ghana (code pays fourni par la source)Établissement de santé
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Twitter (United States) pays non établi dans la noticeEntreprise
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University of Ghana Department of Radiography Accra, Ghana (code pays fourni par la source)Université ou école supérieure
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https://orcid.org/0000-0002-1466-150X pays non établi dans la noticeInstitution
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https://orcid.org/0009-0005-3479-7219 pays non établi dans la noticeInstitution
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https://orcid.org/0000-0003-0742-6007 pays non établi dans la noticeInstitution
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https://orcid.org/0009-0009-8399-4920 pays non établi dans la noticeInstitution
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https://orcid.org/0000-0002-2703-5508 pays non établi dans la noticeInstitution
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https://orcid.org/0000-0003-3485-5368 pays non établi dans la noticeInstitution
Oncology and Nuclear Medicine — Korle Bu Teaching Hospital (Accra, Ghana), Twitter (United States) et Department of Radiography — University of Ghana (Accra, Ghana), avec 6 autres affiliations. Pays d’affiliation : Ghana.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.