Multimorbidity and COVID-19 Outcomes in the Emergency Department: Is the Association Mediated by the Severity of the Condition at Admission?
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Le résumé fourni par la source
Background/Objectives: Charlson Comorbidity Index (CCI) is one of the most reliable indicators to assess the impact of multimorbidity on COVID-19-related outcomes. Moreover, the patient’s clinical conditions are associated with SARS-CoV-2 outcomes. This study aimed to analyze the association between multimorbidity and COVID-19-related outcomes, evaluating whether the National Early Warning Score 2 (NEWS2) mediated these associations. Methods: Data were obtained through the platform “EPICLIN”. We analyzed all patients who tested positive for COVID-19 after accessing the emergency department (ED) of San Luigi Gonzaga (Orbassano) and Molinette (Turin) hospitals from 1 March to 30 June 2020. Different outcomes were assessed: non-discharge from the ED, 30-day mortality, ICU admission/death among hospitalized patients, and length of hospitalization among surviving patients. Two subgroups of patients (<65 and 65+ years old) were analyzed using logistic regressions, Cox models, and mediation analyses. Results: There was a greater risk of not being discharged or dying among those who were younger and with CCI ≥ 2. Moreover, the higher the CCI, the longer the length of hospitalization. Considering older subjects, a greater CCI was associated with a higher risk of death. Regarding the mediation analyses, multimorbidity significantly impacted the hospitalization length and not being discharged in the younger population. Instead, in the older population, the NEWS2 played a mediation role. Conclusions: This research showed that multimorbidity is a risk factor for a worse prognosis of COVID-19. Moreover, there was a strong direct effect of CCI on not being discharged, and the NEWS2 was found to act as mediator in the association between multimorbidity and COVID-19-related outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multimorbidity and COVID-19 Outcomes in the Emergency Department: Is the Association Mediated by the Severity of the Condition at Admission?
- Date Crossref
- 26/11/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Università degli Studi del Piemonte Orientale “Amedeo Avogadro” pays non établi dans la noticeUniversité ou école supérieure
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University of Turin Department of Clinical and Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Novamont (Italy) pays non établi dans la noticeEntreprise
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University of Florence Department of Statistics pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Citta' della Salute e della Scienza di Torino pays non établi dans la noticeÉtablissement de santé
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Ospedale San Luigi Gonzaga pays non établi dans la noticeÉtablissement de santé
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University of Eastern Piedmont Department of Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Unit of Epidemiology pays non établi dans la noticeInstitution
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Unit of Clinical Epidemiology pays non établi dans la noticeÉtablissement de santé
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San Luigi Gonzaga University Hospital Emergency Department and High Dependency Unit pays non établi dans la noticeUniversité ou école supérieure
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Department of Clinical and Biological Sciences — University of Turin et Novamont (Italy), avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.