Validation of in vivo VERDICT fIC against matched histology from whole-mount prostatectomy

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Motivation: Intracellular volume fraction (fIC) maps from VERDICT-MRI have shown potential to improve prostate cancer (PCa) stratification, but the microstructural origin of the signal has not yet been investigated in in vivo settings. Goal(s): Investigate the accuracy of fIC from in vivo VERDICT-MRI as a measurement of cell density using matched prostatectomy specimens. Approach: Using personalised moulds from multiparametric (mp)MRI and deep learning image registration, we align whole prostatectomy histology images with corresponding VERDICT MR images. We compare fIC maps against cell density maps derived from histology. Results: fIC maps show very strong agreement with histology-derived cell density maps of epithelial cells (r=0.8303). Impact: Our study shows that VERDICT fIC maps are accurate descriptors of epithelial cell density in the prostate. The biological interpretability of these maps will facilitate translation into clinical practice, improving PCa stratification from MRI.

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