Anisotropy of Longitudinal Relaxation in White Matter: Comparison of T1 and Magnetization Transfer

Le résumé fourni par la source

Motivation: Studies on the orientation dependence of T1 have led to contradictory observations, indicating that this effect is not well understood. Goal(s): Our primary objective was to meticulously explore the orientation dependency of T₁ under precisely controlled and stable conditions. Approach: Comprehensive T1 (inversion recovery) and magnetization-transfer (MT) experiments were performed in fixed spinal-cord samples, with systematic variation of the fiber-to-field angle θFB . Results: No relevant T1 variation with θFB was observed in the IR experiments. However, a clear orientation dependence was consistently observed in all MT experiments,Impact: Precise quantitative MR measurements in spinal cord with varying fiber-to-field angle showed no consistent orientation dependence of T1 but a clear effect for the MT saturation, indicating the MT effects may be responsible for the previously observed T1 anisotropy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.