Mapping Metabolite and Neurotransmitter Alterations in Mesial Temporal Lobe Epilepsy Using Optimized Multi-TE MRSI: A Preliminary Study

Le résumé fourni par la source

Motivation: Multimodal imaging integrating molecular information promises to improve seizure foci lateralization and disease progression monitoring for mesial temporal lobe epilepsy (mTLE). Goal(s): To evaluate the feasibility of a multi-TE MRSI method optimized for simultaneously mapping metabolites and neurotransmitters in mTLE. Approach: Volumetric multi-TE MRSI and structural MRI data were acquired and analyzed for an mTLE cohort. Regional analysis was performed to quantified molecular maps and hippocampus volumetrics. Results: Reduced NAA/Cr ratios were observed for the ipsilateral hippocampous (epileptic side), consistent with prior findings and overall reduced hippocampus volumes. Reduced Glx/Cr ipsilaterally was observed. Interesting differences in anterior vs. posterior hippocampus were also reported. Impact: We demonstrated the feasibility of a new MRSI technique for mapping metabolic alterations in mTLE patients. Initial results support promise for improved lateralization and better understanding biochemical mechanisms of the disease using MRSI.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.