Quantification of 1H-MRSI metabolites in mild traumatic brain injury using relaxation correction from MRF

Le résumé fourni par la source

Motivation: Accurate 1H-MRS metabolite quantification requires adjustments for metabolite and water signal relaxation, which are challenging to measure. Goal(s): Our goal was to examine whether an MRF-based correction of subject-specific water relaxation times, applied to patients with mild traumatic brain injury (mTBI), yields results and effect sizes comparable with a conventional literature-based correction approach that utilizes one set of relaxation times for all subjects. Approach: MRF and 1H-MRSI were acquired in 21 mTBI patients and 20 age-matched controls for quantification of metabolite concentrations in six white matter regions. Results: Both methods yielded similar findings with comparable effect sizes across all metabolites in all regions. Impact: In the context of intermediate TR and short TE, the standard absolute quantification method based on one literature-derived set of water relaxation times for all subjects may be appropriate for studying white matter metabolism in mild traumatic brain injury.

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