White matter changes across the migraine cycle evaluated with Diffusion Tensor Imaging and the impact of Free Water

Résumé fourni par la source

Motivation: About 25% of female migraine patients suffer from menstrual-related migraine, which has been poorly studied. Goal(s): To identify white matter alterations across the migraine cycle in patients with episodic menstrual-related migraine without aura. Approach: Diffusion MRI allows to assess alterations in the brain tissue microenvironment. Moreover, including the free-water contribution in the diffusion signal can give information about biological mechanisms, such as inflammation, and more directly expose the tissue alterations by removing free water contamination. Results: Significant differences were found in the diffusion parameters of the white matter tracts of the menstrual-related migraine patients. Impact: We found significant alterations in the diffusion parameters of the white matter tracts of episodic menstrual-related migraine patients across migraine cycle using standard diffusion tensor imaging (DTI) and Free-Water corrected DTI.

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