Assessment of Daily Variations of GABA Levels within the Parietal Lobe and Anterior Cingulate Gyrus Regions of Healthy Young Adults Based on MRS.

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Motivation: The assessment of GABA and Glx levels within the brain with MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) has an important role in the diagnosis and treatment of neuropsychiatric disorders. Goal(s): We evaluate the daily fluctuations of GABA levels within the parietal lobe (PL) and anterior cingulate gyrus (ACC) regions. Approach: The GABA+, GABA+/Cr , Glx/Cr ,Glx were measured at six different time points throughout the day using MEGA-PRESS. Results: Significant variations in GABA+/Cr levels within the PL region, with the lowest point occurring at 9:00 and the highest peak occurring at 21:00 . The melatonin levels were positively correlated with GABA+/Cr within the ACC region. Impact: GABA changes in localized brain regions are strongly associated with many psychiatric disorders. The outcomes of this study could be used to guide the diagnosis and treatment of neuropsychiatric disorders.

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