Enhanced Ocular Bioavailability and Prolonged Duration via Hydrophilic Surface Nanocomposite Vesicles for Topical Drug Administration
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Le résumé fourni par la source
BACKGROUND: Internal ocular diseases, such as macular edema, uveitis, and diabetic macular edema require precise delivery of therapeutic agents to specific regions within the eye. However, the eye's complex anatomical structure and physiological barriers present significant challenges to drug penetration and distribution. Traditional eye drops suffer from low bioavailability primarily due to rapid clearance mechanisms. METHODS: The novel ocular drug delivery system developed in this study utilizes poly(lactic-co-glycolic acid) (PLGA) nanoparticles modified with cell-penetrating peptides (CPPs). In vitro drug release studies were conducted to evaluate the sustained-release properties of the nanoparticles. Ex vivo experiments using MDCK cells assessed corneal permeability and uptake efficiency. Additionally, in vivo studies were performed in rabbit eyes to determine the nanoparticles' resistance to elimination by tears and their retention time in the aqueous humor. RESULTS: In vitro drug release studies demonstrated superior sustained-release properties of the nanoparticles. Ex vivo experiments revealed enhanced corneal permeability and increased uptake efficiency by MDCK cells. In vivo studies in rabbit eyes confirmed the nanoparticles' resistance to elimination by lacrimal fluid and their ability to extend retention time in the aqueous humor. CPP modification significantly improved ocular retention, corneal penetration, and cellular endocytosis efficiency. CONCLUSIONS: The CPP-modified PLGA nanoparticles provide an effective and innovative solution for ocular drug delivery, offering improved bioavailability, prolonged retention, and enhanced drug penetration, thereby overcoming the challenges of traditional intraocular drug administration methods.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Enhanced Ocular Bioavailability and Prolonged Duration via Hydrophilic Surface Nanocomposite Vesicles for Topical Drug Administration
- Date Crossref
- 21/11/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guilin Medical University pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory of Advanced Drug Delivery pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Laboratory Animals Monitoring Institute pays non établi dans la noticeStructure de recherche
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Innovation Team (China) pays non établi dans la noticeEntreprise
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Hainan Medical University pays non établi dans la noticeUniversité ou école supérieure
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College of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmacy Key Laboratory of Tropical Translational Medicine of Ministry of Education pays non établi dans la noticeUniversité ou école supérieure
Guilin Medical University, Guangdong Provincial Key Laboratory of Advanced Drug Delivery — Guangdong Pharmaceutical University et Guangdong Laboratory Animals Monitoring Institute, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.