Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022

Le résumé fourni par la source

Acute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between Human Bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. This study aimed to describe the frequency of HBoV in Northern Brazil using samples from AG patients collected between 2017 and 2022. Fecal samples from the viral gastroenteritis surveillance network at the Evandro Chagas Institute (IEC) were analyzed. Fecal suspensions (20%) were prepared, and the viral genome was extracted. PCR and Nested-PCR were employed to detect HBoV, followed by nucleotide sequencing to identify viral types. Out of 692 samples, HBoV positivity was 9.2% (69/693). Genotypes HBoV-1, HBoV-2, HBoV-3, and HBoV-4 were found in 42.5% (17/40), 22.5% (9/40), 33.5% (13/40), and 2.5% (1/40) of the specimens, respectively. Co-infections with HBoV and other enteric viruses occurred in 48.43% (31/64) of cases, with RVA being the most frequent (72.41% or 21/29). The study concludes that HBoV circulates significantly in Northern Brazil and is associated with co-infections. Further research is needed to clarify HBoV role as a causative agent of AG in the region.

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